Ultrasensitive WSe2 field-effect transistor-based biosensor for label-free detection of cancer in point-of-care applications. (20th July 2021)

• Record Type: Journal Article
• Authors: Hossain, Mohammad Mosarof; Shabbir, Babar; Wu, Yingjie; Yu, Wenzhi; Krishnamurthi, Vaishnavi; Uddin, Hemayet; Mahmood, Nasir; Walia, Sumeet; Bao, Qiaoliang; Alan, Tuncay; Mokkapati, Sudha
• Is Part Of: 2D materials. Volume 8:Number 4(2021)
• Publication Date: 2021-07-20
• Subjects: 2D materials -- WSe2 -- field effect transistor (FET) -- biosensor -- prostate cancer; Graphene -- Periodicals; Materials science -- Periodicals; Nanostructured materials -- Periodicals; 620.115
• DOI: 10.1088/2053-1583/ac1253
• Languages: English
• ISSNs: 2053-1583

Abstract

Abstract: We demonstrate a highly sensitive tungsten diselenide (WSe2 ) field-effect transistor (FET) biosensor for label-free detection of early stage prostate cancer. We modified the FET channel by attaching the monoclonal antibody of prostate specific antigen (anti-PSA) through a multi-step process, followed by bovine serum albumin treatment, which ensures specific binding between anti-PSA and PSA. Our FET biosensor has a detection limit of 10 fg m l − 1 PSA, the lowest concentration detected so far by any FET sensor. At this detection limit, the sub-threshold swing is 235 mV de c − 1 ; and the drain current ( I d ) in the FET increases by 70% compared to that in a pristine device. The FET sensor exhibits linear change in threshold voltage ( V th ) and drain current ( I d ) over the detection range of 10 fg m l − 1 –1 ng m l − 1 PSA. Our demonstrated ultra-sensitive and fast WSe2 FET biosensors are promising for point-of-care diagnostics applications.