TRP channels in COVID-19 disease: Potential targets for prevention and treatment. (25th August 2021)

• Record Type: Journal Article
• Authors: Jaffal, Sahar M.; Abbas, Manal A.
• Is Part Of: Chemico-biological interactions. Volume 345(2021)
• Publication Date: 2021-08-25
• Subjects: COVID-19 -- Treatment -- Prevention -- Symptoms -- SARS-CoV-2 -- TRP channels; Biochemistry -- Periodicals; Toxicological chemistry -- Periodicals; Biochemistry -- Periodicals; Biologie moléculaire -- Périodiques; Biochimie -- Périodiques; Toxicologie biochimique -- Périodiques; 572
• DOI: 10.1016/j.cbi.2021.109567
• Languages: English
• ISSNs: 0009-2797

Abstract

Abstract: Coronavirus disease 2019 [COVID-19] is a global health threat caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV2] that requires two proteins for entry: angiotensin-converting enzyme 2 [ACE2] and -membrane protease serine 2 [TMPRSS2]. Many patients complain from pneumonia, cough, fever, and gastrointestinal (GI) problems. Notably, different TRP channels are expressed in various tissues infected by SARS-CoV-2. TRP channels are cation channels that show a common architecture with high permeability to calcium [Ca 2+ ] in most sub-families. Literature review shed light on the possible role of TRP channels in COVID-19 disease. TRP channels may take part in inflammation, pain, fever, anosmia, ageusia, respiratory, cardiovascular, GI and neurological complications related to COVID-19. Also, TRP channels could be the targets for many active compounds that showed effectiveness against SARS-CoV-2. Desensitization or blocking TRP channels by antibodies, aptamers, small molecules or venoms can be an option for COVID-19 prevention and future treatment. This review provides insights into the involvement of TRP channels in different symptoms and mechanisms of SARS-CoV-2, potential treatments targeting these channels and highlights missing gaps in literature. Highlights: Lysosomal TRPML2 channel affects COVID-19 trafficking in endosome, thus viral entry. TRPV4 and TRPC6 channels are implicated in pulmonary edema. TRPM7 channel is involved in pulmonary fibrosis. Several symptoms of COVID-19 result from the activation of TRP channels. Targeting TRP channels can be useful for COVID-19 prevention/treatment.