Thermodynamic inconsistency disproves the Suga-Sagawa theory of cardiac energetics. (September 2021)

• Record Type: Journal Article
• Authors: Loiselle, Denis S.; Taberner, Andrew J.; Tran, Kenneth; Han, June-Chiew
• Is Part Of: Progress in biophysics and molecular biology. Volume 164(2021)
• Page Start: 81
• Page End: 91
• Publication Date: 2021-09
• Subjects: Cardiac thermodynamics -- Enthalpy -- Mechanical efficiency of the myocardium; Biophysics -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular Biology -- Periodicals; Biophysique -- Périodiques; Biochimie -- Périodiques; 571.4
• DOI: 10.1016/j.pbiomolbio.2021.03.002
• Languages: English
• ISSNs: 0079-6107

Abstract

Abstract: The theory proposed by Suga and Sagawa, encompassing the concepts of 'time-varying elastance', 'pressure-volume area' and 'isoefficiency', has been widely applied in cardiac research - albeit not without contention. In this Review, we commence with a brief history of striated muscle energetics as a prelude to re-visiting the Suga-Sagawa Theory. We conclude our discussion by including recent insights into the fundamental flaw underlying the metabolic component of the Theory.