Lack of influence of non-inherited maternal HLA-DR alleles on susceptibility to rheumatoid arthritis. Issue 4 (April 1995)

• Record Type: Journal Article
• Authors: Silman, A J; Hay, E M; Worthington, J; Thomson, W; Pepper, L; Davidson, J; Dyer, P A; Ollier, W E
• Is Part Of: Annals of the rheumatic diseases. Volume 54:Issue 4(1995)
• Page Start: 311
• Page End: 313
• Publication Date: 1995-04
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.54.4.311
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : OBJECTIVE--To reproduce findings from previous reports that non-inherited maternal HLA class II antigens might contribute to rheumatoid arthritis (RA) susceptibility in the offspring. METHODS--Families were recruited from the Arthritis and Rheumatism Council's National Repository of RA families and HLA-DRB1 alleles were examined in these individuals and their first degree relatives using DNA typing methods. RESULTS--There was no evidence of an increase in either non-inherited maternal HLA-DR4 or the HLA-DRB1 shared epitope as a whole compared with the frequency expected using the non-inherited paternal antigens as controls. CONCLUSIONS--The numbers of probands who were shared epitope negative were small, but we are unable to confirm in these families the findings that non-inherited maternal HLA contributes an additional susceptibility factor to rheumatoid arthritis.