Failure of the hydrogen breath test to detect pulmonary sugar malabsorption. Issue 5 (May 1981)

• Record Type: Journal Article
• Authors: Gardiner, A J; Tarlow, M J; Symonds, J; Hutchison, J G; Sutherland, I T
• Is Part Of: Archives of disease in childhood. Volume 56:Issue 5(1981)
• Page Start: 368
• Page End: 372
• Publication Date: 1981-05
• Subjects: Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/adc.56.5.368
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : Five patients with sucrase-isomaltase deficiency, and one patient with primary glucose-galactose malabsorption had no increases in breath hydrogen excretion after oral sucrose or glucose. Anaerobic incubation with sugars of stool suspensions from 5 patients with primary sugar malabsorption produced by trace of hydrogen (17 microliter) in only one, while those from 13 or 14 controls produced a mean hydrogen volume of 640 microliter under similar conditions. Altered bacterial metabolism is a probable explanation. Breath hydrogen excretion did increase appreciably in 2 of these patients after oral lactulose showing that hydrogen excretion may vary according to the substrate. Therefore, observation of breath hydrogen excretion after lactulose is not recommended as a means of predicting false-negative breath tests with other sugars. The hydrogen breath test is not a reliable mean of diagnosing primary sugar malabsorption in children.