Effects of cisapride on QTc interval in neonates. Issue 3 (1st November 1997)

• Record Type: Journal Article
• Authors: Bernardini, S; Semama, D S; Huet, F; Sgro, C; Gouyon, J B
• Is Part Of: Archives of disease in childhood. Volume 77:Issue 3(1997)
• Page Start: F241
• Page End: F243
• Publication Date: 1997-11-01
• Subjects: cisapride -- QT interval -- QTc interval; Infants -- Diseases -- Periodicals; Newborn infants -- Diseases -- Periodicals; Fetus -- Diseases -- Periodicals; 618.920105
• DOI: 10.1136/fn.77.3.F241
• Languages: English
• ISSNs: 1359-2998

Abstract

Abstract : AIM: Prospective survey of the effects of cisapride on QTc interval in neonates given cisapride. METHODS: QTc interval was determined just before and 2.9 (0.9) days after outset of the treatment in 49 neonates treated with cisapride between 1 August 1995 and 29 February 1996. RESULTS: Cisapride significantly increased QTc interval (p = 0.0001), and this was higher when birthweight or gestational age were lower. The prolongation of QTc interval above the arbitrary value of 0.450 (n = 7) was clinically asymptomatic and was significantly more common in the infants born with a gestational age ⩽ 33 weeks (n = 6). CONCLUSION: The findings indicate that cisapride accumulates in less mature neonates. Further pharmacokinetic studies are needed.