DONORS (Donation Network to Optimise Organ Recovery Study): Study protocol to evaluate the implementation of an evidence-based checklist for brain-dead potential organ donor management in intensive care units, a cluster randomised trial. Issue 6 (25th June 2019)

• Record Type: Journal Article
• Authors: Westphal, Glauco Adrieno; Robinson, Caroline Cabral; Biasi, Alexandre; Machado, Flávia Ribeiro; Rosa, Regis Goulart; Teixeira, Cassiano; de Andrade, Joel; Franke, Cristiano Augusto; Azevedo, Luciano Cesar Pontes; Bozza, Fernando; Guterres, Cátia Moreira; da Silva, Daiana Barbosa; Sganzerla, Daniel; do Prado, Débora Zechmeister; Madalena, Itiana Cardoso; Rohden, Adriane Isabel; da Silva, Sabrina Souza; Giordani, Natalia Elis; Andrighetto, Luiza Vitelo; Benck, Patrícia Spessatto; Roman, Fernando Roberto; de Melo, Maria de Fátima Rodrigues Buarque; Pereira, Thattyane Borba; Grion, Cintia Magalhães Carvalho; Diniz, Pedro Carvalho; Oliveira, João Fernando Picollo; Mecatti, Giovana Colozza; Alves, Flávio André Cardona; Moraes, Rafael Barberena; Nobre, Vandack; Hammes, Luciano Serpa; Meade, Maureen O; Nothen, Rosana Reis; Falavigna, Maicon;
• Other Names: author non-byline.; Toribio Cuadra Jose Luis author non-byline.; De Oliveira Caroline Luciane author non-byline.; Rech Gabriela author non-byline.; Passos Gimenes Bruna Dos author non-byline.; Lima Ferraz Siqueira Iris De author non-byline.; Chambi Garrido Aldo Damian author non-byline.; Angelim de Albuquerque Gigliane Maria author non-byline.; Hashimoto Régis Augusto author non-byline.; Teles Mateus Roza author non-byline.; Cruz Rosely Barreiros author non-byline.; Carneiro Pinheiro Júnior Nelson Antônio author non-byline.; Miranda Ferreira de Moraes Janaína Maria author non-byline.; Balzan Claudete Maria author non-byline.; Arana Leite Lúcia Regina author non-byline.; Pinto Oliveira Lis Daniela author non-byline.; Novillo Edwin Fanola author non-byline.; Batista Maxwendell Gomes author non-byline.; De Campos Silvecler Cortijo author non-byline.; Ferreira Marcelo Souza author non-byline.; Figueiredo Helen author non-byline.; Moraes Nathalia Cristina author non-byline.; Lira Matos Paulo Henrique author non-byline.; Feijó Janaína author non-byline.; Andrade Ferreira Dernivania De author non-byline.; Rocha Barrel machado Ana Paula author non-byline.; Santos Poliana Nunes author non-byline.; De oliveira Júnior Lúcio Couto author non-byline.; Ribeiro de Souza Felipe Ferreira author non-byline.; De Oliveira Daniela Cunha author non-byline.; Maria Dias Reis Graças De author non-byline.; Rolim Ana Virgínia author non-byline.; Alencar Lisiane Paiva author non-byline.; Magalhães Samira Rocha author non-byline.; Barbosa de Almeida Eliana Regia author non-byline.; Costa Joel Isidoro author non-byline.; Pontes Carneiro Larissa Salles author non-byline.; Vitorino Sampaio Passos Márcia Maria author non-byline.; Dos Santos Gustavo Martins author non-byline.; Brito de Souza José Wagner author non-byline.; Oliveira Marinho Bruna Bandeira author non-byline.; Salles Júnior Luiz Derwal author non-byline.; Gurgel José Henrique author non-byline.; Fontenele Iranildo Passos author non-byline.; Linhares bezerra Layanny Teles author non-byline.; Leite Júnior Francisco Olon author non-byline.; Da Costa Israel Ferreira author non-byline.; Santos Pinheiro Diego Bruno author non-byline.; De Moura Denise Martins author non-byline.; Bezerra Fernando Albuerne author non-byline.; Cantidio Suzana author non-byline.; Saraiva Medeiros Lima Moreira Jéssica Patrícia author non-byline.; Sousa Carvalho Bruna De author non-byline.; Mendes Ciro Leite author non-byline.; Do Nascimento Igor Mendonça author non-byline.; Dias Juliana Sousa author non-byline.; Gomes Alves Alexandre Augusto author non-byline.; Furtado Oliveira Lima Heloisa Rosário author non-byline.; Cardoso de Araújo Carvalho Silvia Helena author non-byline.; Magalhães Clayton Aragão author non-byline.; Santos Marko Antônio author non-byline.; De Novoa Moraes Luiza Maria author non-byline.; Coutinho Pereira Lea Barroso author non-byline.; Carvalho Novaes Sobrinho Henrique Lott author non-byline.; Araújo Lima Siqueira Sylvia Helena author non-byline.; Da Silva Janaína Rodrigues author non-byline.; De Moraes Samyra Pereira author non-byline.; Walfredo Carvalho Janaína Correia author non-byline.; De Oliveira Kátia Regina author non-byline.; Da Silva Luiz Hamilton author non-byline.; Salomão Pontes Daniela Ferreira author non-byline.; Da Silva Viviane Marçal author non-byline.; Hirata Camila Vieira author non-byline.; Fornaciari Jander Pissinate author non-byline.; Neves Curty Ana Paula author non-byline.; Soares Ivens Guimarães author non-byline.; Oliveira Ferreira Leandro De author non-byline.; Amaral Alexandre author non-byline.; De Gouvêa Guilherme Ono author non-byline.; Cordeiro de Menezes Silveira Ana Paula author non-byline.; De Carvalho Frederico Bruzzi author non-byline.; Ferreira Natasha Preis author non-byline.; Zandona Freitas Sylmara Jenifer author non-byline.; Pena de Sousa Fernanda Coura author non-byline.; Chen Laura author non-byline.; Freitas Morrão Helt Mantuano Pereira Christiane De author non-byline.; Gomes Amélia Cristina author non-byline.; De Oliveira Jeova Ferreira author non-byline.; Baldow Marcela Leandro author non-byline.; Dutra Rodrigo Santana author non-byline.; De Moura Mara Rubia author non-byline.; De Oliveira Claudio Dornas author non-byline.; Moreira Andressa Siuves author non-byline.; De Oliveira Marina Ferreira author non-byline.; Gonçalves Pereira Leal Patrícia Berg author non-byline.; Silva das Neves Ana Paula author non-byline.; Gomes da Silva Rodrigo Correa author non-byline.; Flores Márcia Heloisa author non-byline.; Almeida Roberto De author non-byline.; Zili Couto Karin Aline author non-byline.; Dos Santos Fernandes Alexsandro José author non-byline.; Carvalho Carla Fabíola author non-byline.; De Jesus Capelo Frois Elizabeth Regina author non-byline.; Mezaroba Ana Luiza author non-byline.; Festti Josiane author non-byline.; Dhaese Thomas Markus author non-byline.; Hanke Simone Macedo author non-byline.; Arcaro Guilherme author non-byline.; Ramthun Maikel author non-byline.; Pereira Tomacheski Jullye Christine author non-byline.; Flores César author non-byline.; Cwiertnia Patrícia Bertoncini author non-byline.; Duarte Péricles author non-byline.; Padilha Elaine Fátima author non-byline.; Tchaicka Cleber author non-byline.; Oliveira Ayres Lizandra De author non-byline.; Farias Sheila Esteves author non-byline.; Tanita Marcos Toshyiuki author non-byline.; Queiroz Cardoso Lucienne Tibery author non-byline.; Germano Almir author non-byline.; Dell'Agnolo Catia Milene author non-byline.; De Freitas Rosane Almeida author non-byline.; Barbosa Ellen Sotti author non-byline.; Mezzavila Vanessa Martim author non-byline.; Junior Pedro Rigon author non-byline.; Weiwanko Itamar author non-byline.; Morginski Cristiano author non-byline.; Pasa Junior Waldir Antonio author non-byline.; Zill Risson Ricardo Gustavo author non-byline.; Barbosa santos Fernanda Gabriella author non-byline.; Vieira Mayara Ferreira author non-byline.; Cassolli Tatiana Euclydes author non-byline.; Singer Mariana Pramio author non-byline.; Oliveira Pereira Rosiane De author non-byline.; De Oliveira Jaciara Ribeiro author non-byline.; Slemer Lemos Melina Almeida author non-byline.; Boaretto Toniol Vivianne Cristina author non-byline.; De Souza Mariza Aparecida author non-byline.; Hayashi Ângelo Yassushi author non-byline.; De lima de Paula Priscila Lisane author non-byline.; Lara Bezerra Elza De author non-byline.; Ziger Borges Fernanda Grossmann author non-byline.; Ramos Elaine Silva author non-byline.; Marochi Cibele Aparecida author non-byline.; Braga Jessyca author non-byline.; Oliveira Sodré Alexander De author non-byline.; Pereira Entrago Letícia Alves author non-byline.; Barcelos Thiago Matos author non-byline.; De Jesus Roberta Carvalho author non-byline.; Montez Vitor author non-byline.; França da Silva de Melo Mônica Silvina author non-byline.; Benites vaz Tais Cristina author non-byline.; Santos Vladimir Dos author non-byline.; Cardoso Fábio Fernandes author non-byline.; Mallmann Lucas author non-byline.; Calvi Adriana author non-byline.; Franco Neto Nelson Barbosa author non-byline.; De Oliveira Silveira Manoel Nelson author non-byline.; Fonseca Deisi author non-byline.; Santini Susana author non-byline.; Bonow Fernanda Paiva author non-byline.; Susin Ruth author non-byline.; Mayer Machado Kellen Patrícia author non-byline.; De Aguiar Danielle Molardi author non-byline.; Scheneider Caroline Salim author non-byline.; Braz Lidiane Couto author non-byline.; Pereira do Bem Carlos Francisco author non-byline.; Rech Tatiana Helena author non-byline.; Rodrigues Filho Edison Moraes author non-byline.; De Aquino Vivian Wuerges author non-byline.; Bourscheit Fernando author non-byline.; Marini Luciano author non-byline.; Orlando Bianca Rodrigues author non-byline.; Oliveira Teixeira Luciano De author non-byline.; Bizarro Silvia Zluhan author non-byline.; Mendonça Viviani Aspirot author non-byline.; Calvete José Oliveira author non-byline.; Maito Lina author non-byline.; Henrich Sabrina Frighetto author non-byline.; Pellizzaro Larissa Assunta author non-byline.; Filiponi Thiago Corsi author non-byline.; Pires Barbosa Felipe Fernandes author non-byline.; Gozzoli Flávia author non-byline.; Ribeiro André Scazufka author non-byline.; Penha Rosateli Paulo Henrique author non-byline.; Waked Zeher Mohamad author non-byline.; Quintal Ana Paula author non-byline.; Ajeje lobo Suzana Margareth author non-byline.; Sampaio Regiane author non-byline.; Morais Marcos author non-byline.; Luz Rol James Da author non-byline.; Silva Ferreira Luciana Da author non-byline.; De Stefano Laercio Martins author non-byline.; Cleto Marina Acosta author non-byline.; Kenrnely Silvia Eduara author non-byline.; Banin Cintia author non-byline.; Gomes Douglas Maria Odila author non-byline.; Borba Renato Luis author non-byline.; Boni Daniela author non-byline.; Prado Monteiro Eliza Maria author non-byline.; De oliveira Manoel Airton Leonardo author non-byline.; Neto Ciro Parioto author non-byline.; Martins Siderleny Casari author non-byline.; Lovato Wilson José author non-byline.; Bonvento Marcelo author non-byline.; Cerantola Rodrigo Barbosa author non-byline.; Palma Leonardo Carvalho author non-byline.; Rojas Salomon Ordinola author non-byline.; Veiga Viviane Cordeiro author non-byline.; Telles Raquel author non-byline.; Travassos Phillipe author non-byline.; Marco Roberto author non-byline.; Hirata Fabiano author non-byline.; Vieira Cinthia Consolin author non-byline.; Peraza Ligia author non-byline.; Jackiu Miriam author non-byline.; Resende Freitas Flávio Geraldo author non-byline.; Santiago Alessandra Duarte author non-byline.; Bertin Márcia Rosangela author non-byline.; Otsubo Luiz author non-byline.; Pinatti Marques Ana Laura author non-byline.; Torres Martha Pereira author non-byline.; Dos Santos Gileade Gomes author non-byline.; Gomes Márcia Christina author non-byline.; Soubhia Nunes Caio Lúcio author non-byline.; Moreira Felipe Alves author non-byline.; Ferrari Regiane Clelia author non-byline.; Ramos Daniela Barbosa author non-byline.; Motta Passos Leny Nascimento author non-byline.; Brandão de Melo Sodré América Carolina author non-byline.; Cassia Martins Pinto Pedosa Rita De author non-byline.; Barbosa de Almeida Eliana Regia author non-byline.; Correa Matiello Raquel Duarte author non-byline.; Santos Machado Maria Dos author non-byline.; Castro Fernando author non-byline.; Gonçalves Gustavo Prudente author non-byline.; Gomes de Oliveira Maria Ines author non-byline.; Cancado Junior Omar Lopes author non-byline.; Miozzo Claire Carmen author non-byline.; Melo Moreira Montenegro Gyanna Lys author non-byline.; De Carvalho Gomes Noemy Alencar author non-byline.; Cagol Garcia Badoch Arlene Teresinha author non-byline.; Sarlo Rodrigo Alves author non-byline.; E Mello Pereira Gabriel Teixeira author non-byline.; Medeiros Marques Raissa De author non-byline.; Araújo Toledo Suely Lima author non-byline.; Ruhling Ricardo Klein author non-byline.; Fernandez Benito Oliveira author non-byline.; Spalini Agenor author non-byline.; Medeiros Marizete Peixoto author non-byline.; Coelho Brena Pinheiro author non-byline.; De Araújo Joselio Emar author non-byline.;
• Is Part Of: BMJ open. Volume 9:Issue 6(2019)
• Publication Date: 2019-06-25
• Subjects: brain death -- cardiac arrest -- organ donation -- checklist -- quality improvement; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2018-028570
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Introduction: There is an increasing demand for multi-organ donors for organ transplantation programmes. This study protocol describes the Donation Network to Optimise Organ Recovery Study, a planned cluster randomised controlled trial that aims to evaluate the effectiveness of the implementation of an evidence-based, goal-directed checklist for brain-dead potential organ donor management in intensive care units (ICUs) in reducing the loss of potential donors due to cardiac arrest. Methods and analysis: The study will include ICUs of at least 60 Brazilian sites with an average of ≥10 annual notifications of valid potential organ donors. Hospitals will be randomly assigned (with a 1:1 allocation ratio) to the intervention group, which will involve the implementation of an evidence-based, goal-directed checklist for potential organ donor maintenance, or the control group, which will maintain the usual care practices of the ICU. Team members from all participating ICUs will receive training on how to conduct family interviews for organ donation. The primary outcome will be loss of potential donors due to cardiac arrest. Secondary outcomes will include the number of actual organ donors and the number of organs recovered per actual donor. Ethics and dissemination: The institutional review board (IRB) of the coordinating centre and of each participating site individually approved the study. We requested a waiver of informed consent for the IRB of each site. Study results will be disseminated to the general medical community through publications in peer-reviewed medical journals. Trial registration number: NCT03179020 ; Pre-results.