Autoantibodies against interleukin 1α in rheumatoid arthritis: association with long term radiographic outcome. Issue 7 (1st July 2002)

• Record Type: Journal Article
• Authors: Graudal, N A; Svenson, M; Tarp, U; Garred, P; Jurik, A-G; Bendtzen, K
• Is Part Of: Annals of the rheumatic diseases. Volume 61:Issue 7(2002)
• Page Start: 598
• Page End: 602
• Publication Date: 2002-07-01
• Subjects: autoantibodies -- cytokine -- interleukin 1α -- rheumatoid arthritis; aAb, autoantibodies -- IL, interleukin -- ra, receptor antagonist -- RA, rheumatoid arthritis -- TNF tumour necrosis factor; Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.61.7.598
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Objectives: To investigate the possible association of interleukin 1α autoantibodies (IL1α aAb) with the long term course of joint erosion in patients with rheumatoid arthritis (RA). Methods: Serum samples from 176 patients with RA included in a prospective study over 30 years were analysed for IL1α aAb by binding to human [ 125 I]IL1α. Erosions of 19 diarthrodial joints were radiographically scored by the Larsen method. Results: The relative risk (RR) of early IL1α aAb positive patients developing at least 30% of maximum radiographic joint destruction was significantly lower than for IL1α aAb negative patients, RR=0.29 (p=0.04). In rheumatoid factor positive patients RR was only 0.18 (p=0.02). Patients who seroconverted more than two years after the onset of RA showed the most aggressive development of joint erosion, with a relative risk of at least 40% of maximum radiographic joint destruction of 2.56 (p=0.048) Conclusions: The progression of radiographic joint destruction in patients with RA is associated with, and perhaps modified by, circulating IL1α aAb, suggesting that IL1α or IL1α aAb, or both, have a role in the erosive processes. IL1α aAb appear to be of prognostic significance in RA.