Assessment of anti-inflammatory drugs in the rat using subcutaneous implants of polyurethane foam impregnated with dead tubercle bacilli. Issue 4 (August 1975)

• Record Type: Journal Article
• Authors: Clarke, A K; Vernon-Roberts, B; Currey, H L
• Is Part Of: Annals of the rheumatic diseases. Volume 34:Issue 4(1975)
• Page Start: 326
• Page End: 331
• Publication Date: 1975-08
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.34.4.326
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : The fluid and cellular phases of inflammatory resonse have been measured using a technique employing subcutaneous implantation of polyurethane foam cubes impregnated with heat-killed Mycobacterium tuberculosis. Phenylbutazone, azathioprine, aspirin, cyclophosphamide, and prednisolone suppressed fluid response, whereas sodium aurothiomalate, hydroxychloroquine, and D-penicillamine had no effect. All the drugs used suppressed the infiltration of inflammatory cells into the cubes.