Radical Vaginal Trachelectomy (RVT) Combined With Laparoscopic Lymphadenectomy: Prospective Study of 225 Patients With Early-Stage Cervical Cancer. Issue 8 (1st November 2011)

• Record Type: Journal Article
• Authors: Lanowska, Malgorzata; Mangler, Mandy; Spek, Annabel; Grittner, Ulrike; Hasenbein, Kati; Chiantera, Vito; Hertel, Hermann; Schneider, Achim; Köhler, Christhardt; Speiser, Dorothee
• Is Part Of: International journal of gynecological cancer. Volume 21:Issue 8(2011)
• Page Start: 1458
• Page End: 1464
• Publication Date: 2011-11-01
• Subjects: Early-stage cervical cancer -- Radical vaginal trachelectomy -- Fertility-preserving surgery -- Laparoscopic lymphadenectomy; Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1097/IGC.0b013e3182216aa7
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objective: The aim of the study was to prove the surgical and oncological safety of radical vaginal trachelectomy (RVT) and laparoscopic lymphadenectomy for patients with early-stage cervical cancer who are seeking parenthood. Methods: A database of 225 patients with early-stage cervical cancer and intention to treat by RVT after laparoscopic lymphadenectomy was prospectively maintained. A total of 212 patients were treated according to the protocol. The procedure was preformed in a standardized manner, and life table analysis was applied. Results: In the cohort of patients treated according to protocol, 8 recurrences occurred and 4 patients died from recurrence. The median follow-up time was 37 months (range, 0-171 months). The 5-year recurrence-free and overall survival was 94.4% and 97.4%, respectively. Perioperative and short-term postoperative complications were rare (2.8% and 7.5%, respectively). No severe long-term complications occurred. Conclusions: Radical vaginal trachelectomy combined with laparoscopic lymphadenectomy is a safe method for treatment of patients with early-stage cervical cancer who are seeking parenthood.