A randomised clinical trial comparing 2% econazole and 5% natamycin for the treatment of fungal keratitis. Issue 10 (23rd September 2003)

• Record Type: Journal Article
• Authors: Prajna, N V; John, R K; Nirmalan, P K; Lalitha, P; Srinivasan, M
• Is Part Of: British journal of ophthalmology. Volume 87:Issue 10(2003)
• Page Start: 1235
• Page End: 1237
• Publication Date: 2003-09-23
• Subjects: fungal keratitis -- randomised clinical trial -- econazole -- natamycin; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjo.87.10.1235
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Aim: To compare 2% econazole and 5% natamycin in the management of fungal keratitis. Methods: A randomised clinical trial was performed using 2% econazole or 5% natamycin as the two treatment arms on patients presenting with culture positive fungal keratitis to the cornea service at Aravind Eye Care System, Madurai, India. Results: 116 patients were recruited, and 112 continued in the study. There were no significant differences between the two arms at baseline or for success (defined as a healed or healing ulcer) at final visit (p = 0.79). Conclusions: 2% Econazole appears to be as effective as 5% natamycin for the management of fungal keratitis.