Statin Therapy Reduces Growth of Abdominal Aortic Aneurysms. (1st December 2011)

• Record Type: Journal Article
• Authors: Karrowni, Wassef; Dughman, Saadeddine; Hajj, Georges P.; Miller, Francis J.
• Is Part Of: Journal of investigative medicine. Volume 59:Number 8(2011)
• Page Start: 1239
• Page End: 1243
• Publication Date: 2011-12-01
• Subjects: statins -- atherosclerosis -- abdominal aortic aneurysm; Clinical medicine -- Periodicals; Medicine -- Research -- Periodicals; Medicine; Research -- United States; Clinical medicine; Medicine -- Research; Periodicals; 616.075
• DOI: 10.2310/JIM.0b013e31823548e8
• Languages: English
• ISSNs: 1081-5589

Abstract

Abstract : Background: The aim of this study was to evaluate the influence of statins on the growth of small abdominal aortic aneurysms (AAAs). Methods: We retrospectively examined AAA diameter in 211 patients who had undergone serial imaging surveillance. Results: Patients treated with and without statins were similar regarding age, initial aneurysm size, diagnosis of diabetes and hypertension, and smoking history. Patients receiving statins had a decreased aneurysm growth rate compared with those patients not receiving statins (0.9 mm/y [interquartile range, −1.0 to +1.0] vs 3.2 mm/y [interquartile range, 2.0–4.9], P < 0.0001). This difference in the rate of growth was maintained after adjusting for potential confounding factors. Conclusions: To date, this is the one of the largest retrospective studies demonstrating an association between statin use and decreased growth rate of AAA.