Effect of endogenous pancreatic glucagon on gastric acid secretion in patients with duodenal ulcer before and after parietal cell vagotomy. Issue 5 (May 1981)

• Record Type: Journal Article
• Authors: Loud, F B; Chirstiansen, J; Holst, J J; Petersen, B; Kirkegaard, P
• Is Part Of: Gut. Volume 22:Issue 5(1981)
• Page Start: 359
• Page End: 362
• Publication Date: 1981-05
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.22.5.359
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : The effect of endogenous pancreatic glucagon on submaximal pentagastrin stimulated gastric acid secretion was studied by infusion of 1-arginine in patients with duodenal ulcer before and after parietal cell vagotomy without drainage (PCV). Preoperatively infusion of 1-arginine resulted in a marked inhibition of acid secretion, whereas no effect was found postoperatively. Plasma glucagon concentrations were identical pre- and postoperatively, fasting as well as during arginine infusion. Serum gastrin concentration rose after PCV but not unaffected by arginine infusion both pre- and postoperatively. The study demonstrates that intact vagal innervation of the fundic glands is a condition of inhibition of pentagastrin induced acid secretion by pancreatic glucagon released by infusion of 1-arginine.