Sleep Duration, Sleep Apnea, and Gray Matter Volume. (January 2022)

• Record Type: Journal Article
• Authors: Kim, Regina Eun Young; Abbott, Robert Douglas; Kim, Soriul; Thomas, Robert Joseph; Yun, Chang-Ho; Kim, Hyun; Johnson, Hans; Shin, Chol
• Is Part Of: Journal of geriatric psychiatry and neurology. Volume 35:Number 1(2022)
• Page Start: 47
• Page End: 56
• Publication Date: 2022-01
• Subjects: sleep apnea -- sleep duration -- MRI -- aging; Geriatric neurology -- Periodicals; Geriatric neuropsychiatry -- Periodicals; Geriatric psychiatry -- Periodicals; Nervous system -- Diseases -- Periodicals; 618.97689
• DOI: 10.1177/0891988720988918
• Languages: English
• ISSNs: 0891-9887

Abstract

This study aimed to evaluate the effect of sleep duration on brain structures in the presence versus absence of sleep apnea in middle-aged and older individuals. The study investigated a population-based sample of 2, 560 individuals, aged 49-80 years. The presence of sleep apnea and self-reported sleep duration were examined in relation to gray matter volume (GMV) in total and lobar brain regions. We identified ranges of sleep duration associated with maximal GMV using quadratic regression and bootstrap sampling. A significant quadratic association between sleep duration and GMV was observed in total and lobar brain regions of men with sleep apnea. In the fully adjusted model, optimal sleep durations associated with peak GMV between brain regions ranged from 6.7 to 7.0 hours. Shorter and longer sleep durations were associated with lower GMV in total and 4 sub-regions of the brain in men with sleep apnea.