Granulocytic sarcoma preceding leukaemic transformation in myelofibrosis. Issue 722 (December 1985)

• Record Type: Journal Article
• Authors: Jacobs, P.; Sellars, S.
• Is Part Of: Postgraduate medical journal. Volume 61:Issue 722(1985)
• Page Start: 1069
• Page End: 1071
• Publication Date: 1985-12
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.61.722.1069
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : A granulocytic sarcoma expanded the malar region in a patient with proven myelofibrosis over a 22 month period before undergoing rapid increase in size concomitantly with transformation to acute granulocytic leukaemia in the marrow and the widespread appearance of subcutaneous tumour deposits. Rapid response was obtained with local radiotherapy, and the systemic disease manifestations were controlled on combination courses of oral 4'-demethoxydaunorubicin and the epipodophyllotoxin VP16-213. This appears to be the first example of a granulocytic sarcoma occurring in a patient with myelofibrosis.