Therapeutic non-invasive brain stimulation in amyotrophic lateral sclerosis: rationale, methods and experience. Issue 10 (9th May 2019)

• Record Type: Journal Article
• Authors: Edmond, Evan C; Stagg, Charlotte J; Turner, Martin R
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 90:Issue 10(2019)
• Page Start: 1131
• Page End: 1138
• Publication Date: 2019-05-09
• Subjects: als -- motor neuron disease -- electrical stimulation -- magnetic stimulation -- neurophysiology, expt; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp-2018-320213
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : The neurodegenerative syndrome amyotrophic lateral sclerosis (ALS) is characterised by increased cortical excitability, thought to reflect pathological changes in the balance of local excitatory and inhibitory neuronal influences. Non-invasive brain stimulation (NIBS) has been shown to modulate cortical activity, with some protocols showing effects that outlast the stimulation by months. NIBS has been suggested as a potential therapeutic approach for disorders associated with changes in cortical neurophysiology, including ALS. This article reviews NIBS methodology, rationale for its application to ALS and progress to date.