Paraneoplastic syndrome in vaginal melanoma: a case report and review of the literature. Issue 5 (1st September 2007)

• Record Type: Journal Article
• Authors: Hauspy, J.; Nevin, A.; Harley, I.; Mason, W.; Quirt, I.; Ghazarian, D.; Laframboise, S.
• Is Part Of: International journal of gynecological cancer. Volume 17:Issue 5(2007)
• Page Start: 1159
• Page End: 1163
• Publication Date: 2007-09-01
• Subjects: melanoma -- paraneoplastic syndrome -- vagina; Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1111/j.1525-1438.2006.00857.x
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : The authors of this article present a case of a woman diagnosed with a vaginal melanoma who developed paraneoplastic syndrome (PNS) soon after diagnosis. A review of the literature regarding PNSs in gynecological malignancies is also described in this article. To our knowledge, this is the first reported case of paraneoplastic cerebellar degeneration with opsoclonus myoclonus secondary to a vaginal melanoma. In addition, our patient had an unusually acute progression to pancerebellar symptoms over the course of 3 weeks. Her paraneoplastic symptoms improved significantly after partial resection of the melanoma.