Nomogram for contrast-induced acute kidney injury in patients with chronic kidney disease undergoing coronary angiography in China: a cohort study. Issue 5 (26th May 2020)

• Record Type: Journal Article
• Authors: Lei, Li; Xue, Yan; Guo, Zhaodong; Liu, Bowen; He, Yibo; Liu, Jin; Nie, Zhiqiang; Chen, Liling; Chen, Kaihong; Huang, Zhidong; Liang, Min; Chen, Shiqun; Liu, Yong; Chen, Jiyan
• Is Part Of: BMJ open. Volume 10:Issue 5(2020)
• Publication Date: 2020-05-26
• Subjects: coronary intervention -- acute renal failure -- chronic renal failure; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2020-037256
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Objectives: To establish a nomogram for contrast-induced acute kidney injury (CI-AKI) risk assessment among patients with chronic kidney disease (CKD) undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI). Design: Prospective observational cohort study. Setting: Southern China. Interventions: None. Participants: 643 consecutive patients with CKD (defined as estimated glomerular filtration rate calculated by Modification of Diet in Renal Disease formula <60 mL/min/1.73 mm 2 ) were enrolled. Outcome measures: The end point was CI-AKI defined as serum creatinine elevation ≥0.5 mg/dL or 25% from baseline within the first 48–72 hours following contrast exposure.Predictors of CI-AKI were selected by multivariable logistic regression and stepwise approach. A nomogram based on these predictors was constructed and compared with the classic Mehran Score. For validation, a bootstrap method (1000 times) was performed. Results: The nomogram including age, weight, heart rate, hypotension, PCI and β-blocker demonstrated a better predictive value than the classic Mehran Score (area under the curve: 0.78 vs 0.71, p=0.024), as well as a well-fitted calibration curve (χ 2 =12.146, p=0.145). Validation through the bootstrap method (1000 times) also indicated a good discriminative power (adjusted C-statistic: 0.76). Conclusions: With fewer predictors and higher discriminative power, the present nomogram may be a simple and reliable tool to identify patients with CKD at risk of CI-AKI, whereas further external validations are needed.