Autoimmune pancytopenia following combination chemotherapy for chronic lymphocytic leukaemia. Issue 5 (27th April 2009)

• Record Type: Journal Article
• Authors: MacCallum, S; Groves, M; Brass, D; Cunningham, J; Sales, M; Gelly, K; Tauro, S
• Is Part Of: Journal of clinical pathology. Volume 62:Issue 5(2009)
• Page Start: 468
• Page End: 470
• Publication Date: 2009-04-27
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.2008.061143
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Autoimmune haemolysis or thrombocytopenia can complicate purine nucleoside monotherapy for chronic lymphocytic leukaemia (CLL), but Evans syndrome is rare. This is a report of the occurrence of pancytopenia secondary to a unique combination of red cell aplasia with autoimmune thrombocytopenia and neutropenia in a patient with CLL following treatment with fludarabine and cyclophosphamide. This case is unusual for the simultaneous targeting of three haemopoietic lineages by immune dysfunction following fludarabine and cyclophosphamide, which is a treatment regimen believed to reduce autoimmune haematological toxicity in CLL.