Mobilisation of mesenchymal cells into blood in response to skeletal muscle injury. Issue 8 (28th June 2006)

• Record Type: Journal Article
• Authors: Ramírez, M; Lucia, A; Gómez-Gallego, F; Esteve-Lanao, J; Pérez-Martínez, A; Foster, C; Andreu, A L; Martin, M A; Madero, L; Arenas, J; García-Castro, J
• Is Part Of: British journal of sports medicine. Volume 40:Issue 8(2006)
• Page Start: 719
• Page End: 722
• Publication Date: 2006-06-28
• Subjects: cMSC, circulating mesenchymal stem cell -- MSC, mesenchymal stem cell -- TnI-c, cardiac isoform of troponin I; McArdle's disease -- flow cytomery -- mesenchymal stem cells -- mobilisation -- muscle damage; Sports medicine -- Periodicals; 617.1027
• DOI: 10.1136/bjsm.2006.028639
• Languages: English
• ISSNs: 0306-3674

Abstract

Abstract : Mesenchymal cells recruited to damaged tissues must circulate through the bloodstream. The absolute numbers of circulating mesenchymal stem cells (cMSCs) in two different models of acute and chronic skeletal muscle injury were determined. cMSCs were present in significantly higher numbers in both models than in healthy controls. These results support the hypothesis that MSCs are mobilised into the bloodstream after skeletal muscle tissue damage. These two models (acute and chronic) would be of value in the search for molecular mediators of mobilisation of MSCs into the circulation.