Association of baseline hematoma and edema volumes with one-year outcome and long-term survival after spontaneous intracerebral hemorrhage: A community-based inception cohort study. Issue 7 (October 2021)

• Record Type: Journal Article
• Authors: Loan, James JM; Gane, Angus B; Middleton, Laura; Sargent, Brendan; Moullaali, Tom James; Rodrigues, Mark A; Cunningham, Laura; Wardlaw, Joanna; Salman, Rustam Al-Shahi; Samarasekera, Neshika
• Other Names: Addison Anne non-byline-author.; Ahmad Kate non-byline-author.; Alhadad Syed non-byline-author.; Andrews Peter non-byline-author.; Bisset Elaine non-byline-author.; Bodkin Peter non-byline-author.; Bouhaidar Ralph non-byline-author.; Brennan Paul non-byline-author.; Campbell Brian non-byline-author.; Chandran Siddharthan non-byline-author.; Cook Helen non-byline-author.; Davenport Richard non-byline-author.; Dennis Martin non-byline-author.; Derry Chris non-byline-author.; Dodds Katrina non-byline-author.; Doubal Fergus non-byline-author.; Duncan Susan non-byline-author.; Elder Andrew non-byline-author.; Fitzpatrick Mike non-byline-author.; Foley Peter non-byline-author.; Fouyas Ioannis non-byline-author.; Ghosh Sudipto non-byline-author.; Gibson Rod non-byline-author.; Gordon Claire non-byline-author.; Grant Robin non-byline-author.; Hewett Russell non-byline-author.; Hughes Fiona non-byline-author.; Hughes Mark non-byline-author.; Hunt David non-byline-author.; Hunter Neil non-byline-author.; Ironside James non-byline-author.; Liaquat Imran non-byline-author.; Josephson Colin non-byline-author.; Kamat Anant non-byline-author.; Kealley Susan non-byline-author.; Keir Sarah non-byline-author.; Kerr Gillian non-byline-author.; Kerrigan Simon non-byline-author.; Keston Peter non-byline-author.; King Matthew non-byline-author.; Knight Richard non-byline-author.; Macdonald Elizabeth non-byline-author.; Mackay Graham non-byline-author.; Macleod Donald non-byline-author.; Macleod Malcolm non-byline-author.; Maguire Conor non-byline-author.; Makin Steven non-byline-author.; Mathews Ashok non-byline-author.; Maxwell Fiona non-byline-author.; McClellan Stuart non-byline-author.; Millar Tracey non-byline-author.; Morris Zoe non-byline-author.; Morse Tim non-byline-author.; Mumford Colin non-byline-author.; Murray Katherine non-byline-author.; Myles Lynn non-byline-author.; Nimmo Graham non-byline-author.; Ng Yi non-byline-author.; Pal Suvankar non-byline-author.; Rannikmae Kristiina non-byline-author.; Rhodes Jonathan non-byline-author.; Ross Jerard non-byline-author.; Russell Tim non-byline-author.; Sandercock Peter non-byline-author.; Sellar Robin non-byline-author.; Shanmuganathan Mano non-byline-author.; Shekhar Himanshu non-byline-author.; Simms Henry non-byline-author.; Sittampalam Mara non-byline-author.; Smith Colin non-byline-author.; Soleiman Hamza non-byline-author.; Spiers Helen non-byline-author.; Statham Patrick non-byline-author.; Stavrinos Neo non-byline-author.; Stone Jon non-byline-author.; Stuart Joyce non-byline-author.; Sudlow Cathie non-byline-author.; Summers David non-byline-author.; Taylor Pat non-byline-author.; Torgersen Antonia non-byline-author.; van Dijke Margarethe non-byline-author.; Walker Robert non-byline-author.; Weller Belinda non-byline-author.; Whiteley William non-byline-author.; Whittle Ian non-byline-author.; Will Robert non-byline-author.; Young Wendy non-byline-author.; Anderson Judith non-byline-author.; Broadbent Seona non-byline-author.; Butler Laura non-byline-author.; Caesar Dave non-byline-author.; Cantley Patricia non-byline-author.; Carter Jonathan non-byline-author.; Clegg Gareth non-byline-author.; Coull Andrew non-byline-author.; Crosswaite Alastair non-byline-author.; Dear James non-byline-author.; Dummer Simon non-byline-author.; Duncan Fiona non-byline-author.; Elder-Gracie Trish non-byline-author.; Enright Kate non-byline-author.; Fitzgerald Tom non-byline-author.; Fothergill Jane non-byline-author.; Frier Brian non-byline-author.; Grant David non-byline-author.; Gray Alasdair non-byline-author.; Hart Simon non-byline-author.; Henderson Robin non-byline-author.; Jaap Alan non-byline-author.; Leigh-Smith Simon non-byline-author.; Jones Michael non-byline-author.; Masson Moyra non-byline-author.; McCallum Lynn non-byline-author.; McKechnie Martin non-byline-author.; McKillop Graham non-byline-author.; Mead Gillian non-byline-author.; Morley Wendy non-byline-author.; Morrow Billie non-byline-author.; Morrow Frank non-byline-author.; Murchison Jon non-byline-author.; Murphy Ross non-byline-author.; Ng Jasmine non-byline-author.; Ogundipe Olayinka non-byline-author.; Patel Dilip non-byline-author.; Pollock Alison non-byline-author.; Reed Matthew non-byline-author.; Roberts Geraint non-byline-author.; Selvarajah Johann non-byline-author.; Smith Randy non-byline-author.; Stirling Claire non-byline-author.; Turner Neil non-byline-author.; Wilson Matthew non-byline-author.; Yordanov Stanko non-byline-author.; Bell Nicola non-byline-author.; Chambers Sarah non-byline-author.; Dewar Sandra non-byline-author.; Farquhar Donald non-byline-author.; Harmouche Ali non-byline-author.; Jacob Ashok non-byline-author.; Jackson Katherine non-byline-author.; Knox Anne non-byline-author.; McCafferty Jon non-byline-author.; Moultrie Sam non-byline-author.; Munang Latana non-byline-author.; Noble Donald non-byline-author.; Ramsay Scott non-byline-author.; Spence Linda non-byline-author.; Threlfall Bethany non-byline-author.; Williams Andrew non-byline-author.; Wilson James non-byline-author.; Fitzgerald Alastair non-byline-author.; Jamieson Andrew non-byline-author.; Lange Peter non-byline-author.; McIntosh Andrew non-byline-author.; Morrison Lewis non-byline-author.; Todd Iain non-byline-author.;
• Is Part Of: International journal of stroke. Volume 16:Issue 7(2021)
• Page Start: 828
• Page End: 839
• Publication Date: 2021-10
• Subjects: Cohort study -- intracerebral hemorrhage -- outcome -- peri-hematomal edema -- radiology -- survival; 616.8005
• DOI: 10.1177/1747493020974282
• Languages: English
• ISSNs: 1747-4930

Abstract

Background: Hospital-based studies have reported variable associations between outcome after spontaneous intracerebral hemorrhage and peri-hematomal edema volume. Aims: In a community-based study, we aimed to investigate the existence, strength, direction, and independence of associations between intracerebral hemorrhage and peri-hematomal edema volumes on diagnostic brain CT and one-year functional outcome and long-term survival. Methods: We identified all adults, resident in Lothian, diagnosed with first-ever, symptomatic spontaneous intracerebral hemorrhage between June 2010 and May 2013 in a community-based, prospective inception cohort study. We defined regions of interest manually and used a semi-automated approach to measure intracerebral hemorrhage volume, peri-hematomal edema volume, and the sum of these measurements (total lesion volume) on first diagnostic brain CT performed at ≤3 days after symptom onset. The primary outcome was death or dependence (scores 3–6 on the modified Rankin Scale) at one-year after intracerebral hemorrhage. Results: Two hundred ninety-two (85%) of 342 patients (median age 77.5 y, IQR 68–83, 186 (54%) female, median time from onset to CT 6.5 h (IQR 2.9–21.7)) were dead or dependent one year after intracerebral hemorrhage. Peri-hematomal edema and intracerebral hemorrhage volumes were colinear ( R 2 = 0.77). In models using both intracerebral hemorrhage and peri-hematomal edema, 10 mL increments in intracerebral hemorrhage (adjusted odds ratio (aOR) 1.72 (95% CI 1.08–2.87); p = 0.029) but not peri-hematomal edema volume (aOR 0.92 (0.63–1.45); p = 0.69) were independently associated with one-year death or dependence. 10 mL increments in total lesion volume were independently associated with one-year death or dependence (aOR 1.24 (1.11–1.42); p = 0.0004). Conclusion: Total volume of intracerebral hemorrhage and peri-hematomal edema, and intracerebral hemorrhage volume alone on diagnostic brain CT, undertaken at three days or sooner, are independently associated with death or dependence one-year after intracerebral hemorrhage, but peri-hematomal edema volume is not. Data access statement: Anonymized summary data may be requested from the corresponding author.