Antimicrobial, antimalarial, and cytotoxic substances from the insect pathogenic fungus Beauveria asiatica BCC 16812. (June 2021) - Kornsakulkarn, Jittra
Graphical abstract: Highlights: The constituents of the fungus Beauveria asiatica BCC 16812 were investigated. Six new compounds 1 –6 and two synthetically known compounds 7 and 8 were isolated. Compounds 9 ‒11 exhibited antimalarial, antimicrobial, and cytotoxic activities. 3 S, 9ʹ S configurations of 6 were deduced by application of modified Mosher's method. The 4 R, 9 R configurations of compound 6 were addressed by ECD calculation. Abstract: Six new compounds 1 –6 and two new naturally occurring compounds 7 and 8, together with nine known compounds 9 –14, beauverioride I, dipicolinic acid, and 6-(methoxycarbonyl) picolinic acid were isolated from a wasp-pathogenic fungus Beauveria asiatica, strain BCC 16812. Their structures were determined by extensive spectroscopic analyses. The absolute configurations of compound 6 were established by the application of modified Mosher's method and ECD calculation. Compounds 9 –11 exhibited antimalarial (IC50 0.47–1.79 u g/mL), antimicrobial (MIC 3.13–50.0 u g/mL), and cytotoxic (IC50 0.26–1.23 u g/mL) activities, while compounds 1, 2, 8, and 14 showed only cytotoxicity against Vero cell lines, with IC50 values range 12.96–47.03 u g/mL.