A case report of primary cutaneous marginal zone B-cell lymphoma with mastocytosis. (August 2021)

• Record Type: Journal Article
• Authors: Lee, Hyun Yi; Lee, Joong Sun; Koo, Dae Won
• Is Part Of: SAGE open medical case reports. Volume 9(2021)
• Publication Date: 2021-08
• Subjects: B-cell lymphoma -- mastocytosis -- plasma cells; Clinical medicine -- Case studies -- Periodicals; 616.09
• DOI: 10.1177/2050313X211042527
• Languages: English
• ISSNs: 2050-313X

Abstract

A 53-year-old man presented with asymptomatic, dusky reddish nodules on his trunk, which had persisted for 7 years. Histological findings showed nodular to diffuse dermal infiltration of lymphocytes with irregular nuclei, eosinophils, plasma cells, and mast cells. CD20 revealed patch positivity. Periphery of lymphoid follicles showed BCL-2 positivity and BCL-6 positivity focally at the center. CD30 and toluidine blue staining showed positivity, and several mast cells were confirmed. The immunoglobulin heavy chain gene rearrangement result showed B-cell monoclonality. The patient's condition was diagnosed as cutaneous marginal zone B-cell lymphoma, plasmacytoid type with mastocytosis. Primary cutaneous marginal zone B-cell lymphoma is an indolent lymphoma with a tendency for local recurrence. In the specimen obtained from our patient, multiple mast cells were observed. Primary cutaneous marginal zone B-cell lymphoma with prominent mastocytosis is rare and there are a few reported cases. Therefore, this case is worth reporting for its rarity and for the purpose of reminding mastocytosis in primary cutaneous marginal zone B-cell lymphoma.