Successful combination chemotherapy involving clofarabine, cyclophosphamide, and etoposide for pediatric relapsed acute myeloid leukemia: A case report. (May 2021)

• Record Type: Journal Article
• Authors: Fujita, Sachio; Matsuno, Ryosuke; Kawabata, Naoko; Sugishita, Yumiko; Kaneko, Ryota; Koganesawa, Masaya; Akiyama, Kosuke; Toyama, Daisuke; Yamamoto, Shohei
• Is Part Of: SAGE open medical case reports. Volume 9(2021)
• Publication Date: 2021-05
• Subjects: Clofarabine -- pediatric -- relapsed acute myeloid leukemia; Clinical medicine -- Case studies -- Periodicals; 616.09
• DOI: 10.1177/2050313X211015511
• Languages: English
• ISSNs: 2050-313X

Abstract

Limited salvage chemotherapies are available for relapsed/refractory acute myeloid leukemia. Herein, we described successful reinduction chemotherapy, involving a combination of clofarabine, cyclophosphamide, and etoposide, in a 12-year-old male with relapsed acute myeloid leukemia prior to allogeneic bone marrow transplantation from his father. Although treatment with a combination of fludarabine, cytarabine, granulocyte colony-stimulating factor, idarubicin, and gemtuzumab ozogamicin had no positive effects, the aforementioned clofarabine-based chemotherapy induced complete remission and allowed the transplantation to go ahead. The abovementioned regimen may be useful for induction chemotherapy prior to hematopoietic stem cell transplantation for refractory/relapsed acute myeloid leukemia.