Bladder perivascular epithelioid cell neoplasm: The importance of immunohistochemistry in the diagnosis of an unusual neoplasm. (March 2021)

• Record Type: Journal Article
• Authors: De Noon, Solange; Ayres, Benjamin; Patel, Uday; Issa, Rami; Ho-Yen, Colan Maxwell
• Is Part Of: SAGE open medical case reports. Volume 9(2021)
• Publication Date: 2021-03
• Subjects: Perivascular epithelioid cell neoplasm -- bladder -- urology -- histology -- immunohistochemistry -- differential diagnosis; Clinical medicine -- Case studies -- Periodicals; 616.09
• DOI: 10.1177/2050313X211000868
• Languages: English
• ISSNs: 2050-313X

Abstract

Perivascular epithelioid cell neoplasms represent a group of uncommon mesenchymal tumours with as yet undiscovered benign counterpart. Although perivascular epithelioid cell neoplasms have been described arising in most organ systems as well as in soft tissue and bone, only a small number of perivascular epithelioid cell neoplasms have been reported in the bladder. To date, there is no agreed system for predicting the behaviour of these tumours. We describe a case of a perivascular epithelioid cell neoplasm of the bladder arising in a 57-year-old male and initially diagnosed on biopsy and present a review of the literature focussing on the pathological differential diagnosis and the importance of key histological features in conjunction with a broad immunohistochemical panel. This case report highlights the key features of bladder perivascular epithelioid cell neoplasms that distinguishes these rare neoplasms from other bladder lesions.