Self-powered pulsed direct current stimulation system for enhancing osteogenesis in MC3T3-E1. (July 2021)

• Record Type: Journal Article
• Authors: Zhang, Yingzi; Xu, Lingling; Liu, Zhuo; Cui, Xi; Xiang, Zhuo; Bai, Jinyu; Jiang, Dongjie; Xue, Jiangtao; Wang, Chan; Lin, Youxi; Li, Zhe; Shan, Yizhu; Yang, Yuan; Bo, Lin; Li, Zhou; Zhou, Xiaozhong
• Is Part Of: Nano energy. Volume 85(2021)
• Publication Date: 2021-07
• Subjects: Electrical stimulation -- Pulsed direct current -- Self-powered -- Nanogenerator -- Osteoblast; Nanoscience -- Periodicals; Nanotechnology -- Periodicals; Nanostructured materials -- Periodicals; Power resources -- Technological innovations -- Periodicals; Nanoscience; Nanostructured materials; Nanotechnology; Power resources -- Technological innovations; Periodicals; 621.042
• DOI: 10.1016/j.nanoen.2021.106009
• Languages: English
• ISSNs: 2211-2855

Abstract

Abstract: Promoting the differentiation of osteoblasts is critical to maintain bone homeostasis for treatment osteoporosis and fracture healing. For these orthopedic diseases, a portable, highly patient compliance therapy device remains a great challenge. Here, we proposed a biomechanical-energy-driven shape memory piezoelectric nanogenerator (sm-PENG) that integrated with fixation splint to promote osteogenic differentiation. The pulsed direct current (DC) generated from the sm-PENG effectively promote MC3T3-E1 preosteoblast cell proliferation, orientation and increase intracellular calcium ion. At the same time, the ALP activity of cells is also improved by pulsed-DC under long-term culture conditions. Ultimately, increasing calcium deposition, extracellular matrix mineralization and osteogenesis. Our work demonstrates the potential of sm-PENG as a power source for pulsed-DC stimulation of bone repair, and shows great prospect self-powered and portable electronic medical device. Graphical Abstract: An integrated self-powered pulsed-DC stimulation device based on shape memory piezoelectric nanogenerator with arch structure and fracture fixation splint used for bone repair. ga1 Highlights: A shape-memory piezoelectric nanogenerator (sm-PENG) integrated with fixation splint was proposed with good flexibility. The sm-PENG is fabricated by thermo forming technology. This novel structure can better meet the requirement of therapy. The effect of self-powered pulsed direct current stimulation can enhance osteogenesis was studied for the first time.