Clinical Problem Solving: An Older Woman With Weakness from Head to Toe. (January 2022)

• Record Type: Journal Article
• Authors: Hartmann, David A.; Bock, Meredith; Douglas, Vanja; Gerdts, Josiah; Ramani, Biswarathan; Shah, Maulik
• Is Part Of: Neurohospitalist. Volume 12:Number 1(2022)
• Page Start: 177
• Page End: 182
• Publication Date: 2022-01
• Subjects: autoimmune diseases of the nervous system -- neuromuscular disease -- clinical specialty -- myositis -- neuromuscular diseases -- muscular diseases -- neuromuscular diseases -- education -- techniques; Nervous system -- Diseases -- Periodicals; Neurology -- Periodicals; 616.8
• DOI: 10.1177/19418744211005321
• Languages: English
• ISSNs: 1941-8744

Abstract

A 67-year-old woman was admitted to our hospital for progressive weakness, dysphagia, muscle pain, and weight loss. Here we detail the clinical problem solving involved in diagnosing and treating her immune-mediated necrotizing myopathy caused by anti-HMGCoA reductase autoantibodies. Interestingly, this diagnosis coincided with discovery of a gastrointestinal stromal tumor (GIST) and positivity for anti-nuclear matrix protein (anti-NXP2), another myositis specific autoantibody.