Antidiabetic, anticholinergic and antioxidant activities of aerial parts of shaggy bindweed (Convulvulus betonicifolia Miller subsp.) – profiling of phenolic compounds by LC-HRMS. Issue 5 (May 2021)

• Record Type: Journal Article
• Authors: Bingol, Zeynebe; Kızıltaş, Hatice; Gören, Ahmet C.; Kose, Leyla Polat; Topal, Meryem; Durmaz, Lokman; Alwasel, Saleh H.; Gulcin, İlhami
• Is Part Of: Heliyon. Volume 7:Issue 5(2021)
• Publication Date: 2021-05
• Subjects: Shaggy bindweed -- Convulvulus betonicifolia -- Antioxidant activity -- Polyphenol content -- LC-HRMS; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2021.e06986
• Languages: English
• ISSNs: 2405-8440

Abstract

Abstract: In order to evaluate the antioxidant activity of evaporated ethanolic extract (EESB) and lyophilized water extract (WESB) of Shaggy bindweed ( Convulvulus betonicifolia Mill. Subs), some putative antioxidant methods such as DPPH· scavenging activity, ABTS + scavenging effect, ferric ions (Fe 3+ ) reduction method, cupric ions (Cu 2+ ) reducing capacity, and ferrous ions (Fe 2+ ) binding activities were separately performed. Also, ascorbic acid, α-tocopherol and BHT were used as the standard compounds. Additionally, some phenolic compounds that responsible for antioxidant abilities of EESB and WESB were screened by liquid chromatography-high resolution mass spectrometry (LC-HRMS). At the same concentration, EESB and WESB demonstrated effective antioxidant abilities when compared to standards. In addition, EESB demonstrated IC50 values of 1.946 μg/mL against acetylcholinesterase (AChE), 0.815 μg/mL against α-glycosidase and 0.675 μg/mL against α-amylase enzymes. Abstract : Shaggy bindweed; Convulvulus betonicifolia; antioxidant activity; polyphenol content; LC-HRMS.