Three sesquiterpenes from the marine-alga-epiphytic fungus Trichoderma hamatum Z36-7. (June 2021)

• Record Type: Journal Article
• Authors: Ma, Xin-Yue; Song, Yin-Ping; Shi, Zhen-Zhen; Ji, Nai-Yun
• Is Part Of: Phytochemistry letters. Volume 43(2021)
• Page Start: 98
• Page End: 102
• Publication Date: 2021-06
• Subjects: Trichoderma hamatum -- Terpene -- Sesquiterpene -- Cyclonerane -- Trichothecane; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2021.03.020
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Three new sesquiterpenes (1 −3 ) were characterized from Trichoderma hamatum . Compound 2 is the first 4-hydroxylated derivative of cyclonerane sesquiterpenes. Compound 3 is the first natural isolate of halogenated trichothecane derivatives. Abstract: Two new cyclonerane sesquiterpenes, 5-hydroxyepicyclonerodiol oxide (1 ) and 4-hydroxyepicyclonerodiol oxide (2 ), and one new naturally occurring halogenated trichothecane derivative, trichodermol chlorohydrin (3 ), were isolated from Trichoderma hamatum Z36−7, an epiphytic fungal strain obtained from the marine red alga Grateloupia sp. Their structures and relative configurations were assigned on the basis of spectroscopic techniques, including 1D/2D NMR and IR as well as MS. Compound 2 features an unusual 4-hydroxy group on the five-membered ring of cycloneranes, and 3 is the first natural isolate of halogenated trichothecanes. These isolates represent the first occurrence of terpenes in T. hamatum and exhibit growth inhibition of several bacteria and phytoplankton species.