Polythosides A and B, two new triterpenoid saponins from the roots of Acacia polyacantha Willd. (Mimosaceae). (June 2021)

• Record Type: Journal Article
• Authors: Tchoukoua, Abdou; Tomfeun Nganou, Sandrine Carole; Dabole, Bernard; Yoshida, Jun; Ito, Yoshiaki; Ngadjui, Bonaventure Tchaleu; Shiono, Yoshihito
• Is Part Of: Phytochemistry letters. Volume 43(2021)
• Page Start: 190
• Page End: 195
• Publication Date: 2021-06
• Subjects: Acacia polyacantha -- Mimosaceae -- Triterpenoid saponins -- Cytotoxicity -- H4IIE hepatoma cell line; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2021.04.007
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Two new triterpenoid saponins were isolated from Acacia polyacantha . Their structures were elucidated by analysis of 1D and 2D-NMR studies. They were not significantly cytotoxic to H4IIE cells even at 100 μM. Abstract: Two new oleanane-type triterpene saponins, named polythosides A and B (1 and 2 ), together with a known compound, silphioside E (3 ), were isolated from the roots of Acacia polyacantha . Their structures were elucidated by analysis of 1D and 2D-NMR experiments, and mass spectrometry (HR-ESITOF-MS) as oleanolic acid 3- O - β -d -galactopyranosyl-(1→2)- β -d -xylopyranosyl-(1→6)-[ β -d -xylopyranosyl-(1→4)]-[ β -d -xylopyranosyl-(1→2)]- β -d -galactopyranoside (1 ), 3- O -[ β -d -galactopyranosyl-(1→2)- β -d -xylopyranosyl-(1→6)-[ β -d -xylopyranosyl-(1→4)]-[ β -d -xylopyranosyl-(1→2)]- β -d -galactopyranosyl] oleanolic acid-28- O - β -d -glucopyranosyl ester (2 ) and 3- O - β -d -glucopyranosyl-(1→2)- β -d -glucopyranosyl] oleanolic acid 28- O - β -d -glucopyranosyl ester (3 ). The cytotoxic effect of isolated saponins was evaluated on the H4IIE rat hepatoma cell line. The results show that none of the compounds (assayed at 100 μM) showed cytotoxicity against H4IIE cells.