A Case of Intravascular Diffuse Large B-Cell Lymphoma Initially Suspected as Interstitial Pneumonia Associated With Systemic Scleroderma. (March 2021)

• Record Type: Journal Article
• Authors: Oguri, Tomoyo; Sasada, Shinji; Aramaki-Sumii, Yuki; Tsuchiya, Yumi; Ishioka, Kota; Takahashi, Saeko; Kunieda, Hisako; Kimura, Yoshifumi; Seki, Reishi; Hirose, Shigemichi; Nakamura, Morio
• Is Part Of: Journal of investigative medicine high impact case reports. Volume 9(2021)
• Publication Date: 2021-03
• Subjects: anti-centromere antibody -- ground-glass opacity -- intravascular diffuse large B-cell lymphoma -- serum lactate dehydrogenase -- random skin biopsy; Internal medicine -- Periodicals; Medical care -- Periodicals; 616.005
• DOI: 10.1177/2324709621999226
• Languages: English
• ISSNs: 2324-7096

Abstract

Intravascular large B-cell lymphoma (IVLBCL) is a rare form of diffuse LBCL. The patient was a 71-year-old female admitted to our hospital with hypoxia. On admission, chest computed tomography revealed a ground-glass opacity. Interstitial pneumonia associated with systemic scleroderma was suspected because of positive anti-centromere antibody. Thereafter, steroid pulse therapy and plasma exchange were performed. Although ground-glass opacity improved, bilateral pleural effusion appeared, so we performed a random skin biopsy because of her elevated serum lactate dehydrogenase and soluble interleukin-2 receptor levels. The patient was diagnosed with IVLBCL with symptoms improving after 6 cycles of rituximab plus chemotherapy treatment.