Nitrofurantoin-Associated Acute Granulomatous Interstitial Nephritis. (March 2021)

• Record Type: Journal Article
• Authors: Anupama, B. K.; Sampat, Parth; Gambhir, Harvir S.
• Is Part Of: Journal of investigative medicine high impact case reports. Volume 9(2021)
• Publication Date: 2021-03
• Subjects: nitrofurantoin -- acute interstitial nephritis -- granulomatous interstitial nephritis -- acute kidney injury; Internal medicine -- Periodicals; Medical care -- Periodicals; 616.005
• DOI: 10.1177/23247096211001659
• Languages: English
• ISSNs: 2324-7096

Abstract

We report the case of a 71-year-old female who was incidentally found to have nonoliguric acute kidney injury on a routine workup for new-onset visual hallucination. Further history revealed inadvertent usage of nitrofurantoin for 3 months for an anticipated urological procedure. Renal biopsy demonstrated acute granulomatous interstitial nephritis. The renal function significantly improved following discontinuation of nitrofurantoin and corticosteroid administration. We highlight a rare association of nitrofurantoin with acute granulomatous interstitial nephritis through this case report.