Antibacterial and modulatory activities of β-cyclodextrin complexed with (+)-β-citronellol against multidrug-resistant strains. (July 2021)

• Record Type: Journal Article
• Authors: Silva Pereira, Raimundo Luiz; Campina, Fábia Ferreira; Costa, Maria do Socorro; Pereira da Cruz, Rafael; Sampaio de Freitas, Thiago; Lucas dos Santos, Antonia Thassya; Cruz, Beatriz Gonçalves; Maciel de Sena Júnior, Diniz; Campos Lima, Igor Kleber; Xavier, Maria Regivânia; Rodrigues Teixeira, Alexandre Magno; Alencar de Menezes, Irwin Rose; Quintans-Júnior, Lucindo José; Araújo, Adriano A. de S.; Melo Coutinho, Henrique Douglas
• Is Part Of: Microbial pathogenesis. Volume 156(2021)
• Publication Date: 2021-07
• Subjects: Antibacterial activity -- Modulatory-antibiotic activity -- Infrared spectroscopy -- β-Citronellol -- β-Cyclodextrin -- β-Citronellol/β-Cyclodextrin complex; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2021.104928
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: The present study aimed to investigate the antibacterial and modulatory activities of (+)-β-citronellol (βCT), β-cyclodextrin (β-CD), and their complex βCT/β-CD and characterize them using infrared spectroscopy. Infrared spectra were recorded in the 750–4000 cm −1 region. The antibacterial effects of these compounds and their modulatory-antibiotic activities were determined using the minimum inhibitory concentration (MIC) test. Signatures of these pure compounds were detected in the infrared spectrum of the βCT/β-CD complex. The MIC of the βCT/β-CD complex against the tested strains was found to be 1024 μg/mL. The antagonistic and synergistic effects of these compounds were also observed using the modulation tests. βCT or β-CD alone did not exhibit any direct antibacterial activity. However, the βCT/β-CD complex in combination with gentamicin showed a synergistic effect against E. coli . Highlights: The β-CD/βCT complex and pure β-CD did not possess direct antibacterial activity. The β-CD/βCT complex and pure β-CD, WHEN associated with antibiotics displayed synergistic effects. The β-CD/βCT complex in association with gentamicin showed a synergistic effect against E. coli.