Expanding Phenotype of ATP1A3 - Related Disorders: A Case Series. (November 2021)

• Record Type: Journal Article
• Authors: De Vrieze, Jelena; van de Laar, Ingrid M.B.H.; de Rijk-van Andel, Johanneke F.; Kamsteeg, Erik-Jan; Kotsopoulos, Irene A.W.; de Man, Stella A.
• Is Part Of: Child neurology open. Volume 8(2021)
• Publication Date: 2021-11
• Subjects: ATP1A3 gene -- AHC -- RDP -- RECA -- genetics -- intermediate phenotype; Pediatric neurology -- Periodicals; 618.928005
• DOI: 10.1177/2329048X211048068
• Languages: English
• ISSNs: 2329-048X

Abstract

Neurologic disorders caused by mutations in the ATP1A3 gene were originally reported as three distinct rare clinical syndromes: Alternating Hemiplegia of Childhood (AHC), Rapid-onset Dystonia Parkinsonism (RDP) and Cerebellar ataxia, Areflexia, Pes cavus, Opticus atrophy and Sensorineural hearing loss (CAPOS). In this case series, we describe 3 patients. A mother and her daughter showed an intermediate phenotype different from each other with the same heterozygous missense mutation (p.[R756C]), recently described in literature as Relapsing Encephalopathy With Cerebellar Ataxia (RECA). In addition, a third patient showed an intermediate AHC-RDP phenotype and had a likely pathogenic novel de novo missense mutation (p.[L100 V]). These patients support the growing evidence that AHC, RDP and RECA are part of a continuous ATP1A3 mutation spectrum that is still expanding. Three common features were a sudden onset, asymmetrical neurological symptoms, as well as the presence of triggering factors. When present, the authors argue to perform exome sequencing in an early stage.