Are tyrosine kinase inhibitors an effective treatment in testicular metastases from kidney cancer? Case report. Issue 6 (December 2021)

• Record Type: Journal Article
• Authors: Turco, Fabio; Tucci, Marcello; Di Stefano, Rosario Francesco; Samuelly, Alessandro; Bungaro, Maristella; Bollito, Enrico; Scagliotti, Giorgio Vittorio; Buttigliero, Consuelo
• Is Part Of: Tumori. Volume 107:Issue 6(2021)
• Page Start: NP149
• Page End: NP154
• Publication Date: 2021-12
• Subjects: Testicular metastases -- renal cell carcinoma -- tyrosine kinase inhibitors -- TKI -- cabozantinib -- blood–testicular barrier; Cancer -- Periodicals; 616.994
• DOI: 10.1177/03008916211059230
• Languages: English
• ISSNs: 0300-8916

Abstract

Testicular metastases from renal cell carcinoma (RCC) are extremely rare. Tyrosine kinase inhibitors (TKI) are the cornerstone of systemic therapy for metastatic RCC. We report a case of testicular metastasis in a 72-year-old patient with RCC that developed 17 years after nephrectomy and response to TKI treatment, a retrospective literature search on testicular metastases from RCC, and the indirect evidence described in the literature on the efficacy of chemotherapy and target therapy on testicular lesions.