Characterising the long-term clinical outcomes of 1190 hospitalised patients with COVID-19 in New York City: a retrospective case series. Issue 6 (2nd June 2021)

• Record Type: Journal Article
• Authors: Shoucri, Sherif M; Purpura, Lawrence; DeLaurentis, Clare; Adan, Matthew A; Theodore, Deborah A; Irace, Alexandria Lauren; Robbins-Juarez, Shelief Y; Khedagi, Apurva M; Letchford, Daniel; Harb, Amro A; Zerihun, Lillian M; Lee, Kate E; Gambina, Karen; Lauring, Max C; Chen, Noah; Sperring, Colin P; Mehta, Sanket S; Myers, Ellen L; Shih, Hueyjong; Argenziano, Michael G; Bruce, Samuel L; Slater, Cody L; Tiao, Jonathan R; Natarajan, Karthik; Hripcsak, George; Chen, Ruijun; Yin, Michael T; Sobieszczyk, Magdalena E; Castor, Delivette; Zucker, Jason E
• Is Part Of: BMJ open. Volume 11:Issue 6(2021)
• Publication Date: 2021-06-02
• Subjects: COVID-19 -- infectious diseases -- virology; Medicine -- Research -- Periodicals; 610.72
• DOI: 10.1136/bmjopen-2021-049488
• Languages: English
• ISSNs: 2044-6055

Abstract

Abstract : Objective: To characterise the long-term outcomes of patients with COVID-19 admitted to a large New York City medical centre at 3 and 6 months after hospitalisation and describe their healthcare usage, symptoms, morbidity and mortality. Design: Retrospective cohort through manual chart review of the electronic medical record. Setting: NewYork-Presbyterian/Columbia University Irving Medical Center, a quaternary care academic medical centre in New York City. Participants: The first 1190 consecutive patients with symptoms of COVID-19 who presented to the hospital for care between 1 March and 8 April 2020 and tested positive for SARS-CoV-2 on reverse transcriptase PCR assay. Main outcome measures: Type and frequency of follow-up encounters, self-reported symptoms, morbidity and mortality at 3 and 6 months after presentation, respectively; patient disposition information prior to admission, at discharge, and at 3 and 6 months after hospital presentation. Results: Of the 1190 reviewed patients, 929 survived their initial hospitalisation and 261 died. Among survivors, 570 had follow-up encounters (488 at 3 months and 364 at 6 months). An additional 33 patients died in the follow-up period. In the first 3 months after admission, most encounters were telehealth visits (59%). Cardiopulmonary symptoms (35.7% and 28%), especially dyspnoea (22.1% and 15.9%), were the most common reported symptoms at 3-month and 6-month encounters, respectively. Additionally, a large number of patients reported generalised (26.4%) or neuropsychiatric (24.2%) symptoms 6 months after hospitalisation. Patients with severe COVID-19 were more likely to have reduced mobility, reduced independence or a new dialysis requirement in the 6 months after hospitalisation. Conclusions: Patients hospitalised with SARS-CoV-2 infection reported persistent symptoms up to 6 months after diagnosis. These results highlight the long-term morbidity of COVID-19 and its burden on patients and healthcare resources.