Microfluidics: Direct and Label‐Free Cell Status Monitoring of Spheroids and Microcarriers Using Microfluidic Impedance Cytometry (Small 21/2021). Issue 21 (27th May 2021)

• Record Type: Journal Article
• Authors: Gong, Lingyan; Petchakup, Chayakorn; Shi, Pujiang; Tan, Pei Leng; Tan, Lay Poh; Tay, Chor Yong; Hou, Han Wei
• Is Part Of: Small. Volume 17:Issue 21(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-05-27
• Subjects: biomanufacturing -- impedance cytometry -- label‐free -- microfluidics -- stem cell differentiation; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202170101
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Non‐invasive and real‐time monitoring of microcarriers and three‐dimensional cell cultures are important in biomanufacturing and bioprocesses. In article number 2007500, Han Wei Hou and co‐workers introduce a low‐cost microfluidic impedance cytometer with Field's metal electrodes for label‐free and continuous‐flow monitoring of spheroids/microcarriers based on changes in impedance signatures. Potential applications include tracking of cell proliferation (biomass), cell viability and stem cell differentiation on hydrogel and commercial microcarriers.