Γ‐Fe2O3@HAp@PBABMD@Cu magnetic nanoparticles: Efficient, green, and recyclable novel nanocatalyst for the synthesis of densely functionalized pyrrole‐pyrido[2, 3‐d]pyrimidine hybrids. Issue 5 (28th January 2021)

• Record Type: Journal Article
• Authors: Saberikhah, Elham; Mamaghani, Manouchehr; Mahmoodi, Nosrat Ollah
• Is Part Of: Journal of the Chinese Chemical Society. Volume 68:Issue 5(2021)
• Page Start: 902
• Page End: 916
• Publication Date: 2021-01-28
• Subjects: heterogeneous nanocatalyst -- pyrido[2, 3‐d]pyrimidine -- pyrrole -- thiouracils -- three‐component reaction; Chemistry -- Periodicals; Electronic journals; 540.5
• DOI: 10.1002/jccs.202000310
• Languages: English
• ISSNs: 0009-4536

Abstract

Abstract: A green heterogeneous nanocatalyst, Cu(II)‐PBABMD complex immobilized on core‐shell magnetic γ‐Fe2 O3 @HAp, was successfully designed, synthesized, and characterized by FTIR, XRD, FESEM, EDX, VSM, TGA, BET, ICP‐OES, and TEM techniques. The magnetic Cu(II) nanocatalyst was employed as a novel, ecofriendly, recyclable, and safe catalyst for the one‐pot, three‐component condensation of 6‐amino‐2‐thioxo‐2, 3‐dihydropyrimidin‐4(1 H )‐one, 3‐(1‐methyl‐1 H ‐pyrrol‐2‐yl)‐3‐oxopropanenitrile and aromatic aldehydes to produce new pyrido[2, 3‐ d ]pyrimidine derivatives, in refluxing EtOH with excellent yield (90–97%) and short reaction time (8–13 min). The nanocatalyst was used and recycled in eight runs without significant leaching or loss of its catalytic activity. Abstract : A novel heterogeneous nanocatalyst, Cu(II)‐PBABMD complex immobilized on core‐shell magnetic γ‐Fe2 O3 @HAp, was successfully synthesized and employed in the one‐pot, three‐component preparation of new pyrrole‐pyrido[2, 3‐ d ]pyrimidine hybrids with excellent yield (90–97%) and short reaction time (8–13 min).