Joint and tendon involvement predict disease progression in systemic sclerosis: a EUSTAR prospective study. Issue 1 (27th August 2014)

• Record Type: Journal Article
• Authors: Avouac, Jérôme; Walker, Ulrich A; Hachulla, Eric; Riemekasten, Gabriela; Cuomo, Giovanna; Carreira, Patricia E; Caramaschi, Paola; Ananieva, Lidia P; Matucci-Cerinic, Marco; Czirjak, Laszlo; Denton, Christopher; Ladner, Ulf Müller; Allanore, Yannick
• Other Names: author non-byline.; Guiducci Serena author non-byline.; Tyndall Alan author non-byline.; Lapadula Giovanni author non-byline.; Iannone Florenzo author non-byline.; Distler Oliver author non-byline.; Becvar Radim author non-byline.; Sierakowsky Stanislaw author non-byline.; Bielecka Otylia Kowal author non-byline.; Cutolo Maurizio author non-byline.; Sulli Alberto author non-byline.; Valentini Gabriele author non-byline.; Vlachoyiannopoulos Panayiotis G. author non-byline.; Montecucco Carlomaurizio author non-byline.; Caporali Roberto author non-byline.; Novak Srdan author non-byline.; Chizzolini Carlo author non-byline.; Kucharz Eugene J. author non-byline.; Kotulska Anna author non-byline.; Cozzi Franco author non-byline.; Rozman Blaz author non-byline.; Mallia Carmel author non-byline.; Coleiro Bernard author non-byline.; Gabrielli Armando author non-byline.; Farge-Bancel Dominique author non-byline.; Hadj-Khelifa Sondess author non-byline.; Airò Paolo author non-byline.; Hesselstrand Roger author non-byline.; Scheja Agneta author non-byline.; Martinovic Duska author non-byline.; Gurman Alexandra Balbir author non-byline.; Braun-Moscovici Yolanda author non-byline.; Hunzelmann Nicolas author non-byline.; Pellerito Raffaele author non-byline.; Bambara Lisa Maria author non-byline.; Morovic-Vergles Jadranka author non-byline.; Black Carol author non-byline.; Damjanov Nemanja author non-byline.; Kötter Ina author non-byline.; Santamaria Vera Ortiz author non-byline.; Heitmann Stefan author non-byline.; Krasowska Dorota author non-byline.; Seidel Matthias author non-byline.; Hasler Paul author non-byline.; Burkhardt Harald author non-byline.; Himsel Andrea author non-byline.; Silva José Antonio Pereira Da author non-byline.; Salvador Maria João author non-byline.; Stamenkovi Bojana author non-byline.; Stankovic Aleksandra author non-byline.; Marasini Bianca author non-byline.; Belloli Laura author non-byline.; Tikly Mohammed author non-byline.; Denisov Lev N. author non-byline.; Scorza Raffaella author non-byline.; Engelhart Merete author non-byline.; Strauss Gitte author non-byline.; Szücs Gabriella author non-byline.; Szamosi Szilvia author non-byline.; de la Puente Carlos author non-byline.; de la Pena Lefebvre Paloma García author non-byline.; Midtvedt Øyvind author non-byline.; Garen Torhild author non-byline.; Launay David author non-byline.; Valesini Guido author non-byline.; Riccieri Valeria author non-byline.; Ionescu Ruxandra Maria author non-byline.; Opris Daniela author non-byline.; Wigley Fredrick M. author non-byline.; Stoica Viktor author non-byline.; Mihai Carmen Marina author non-byline.; Distler Jörg author non-byline.; Meroni Pierluigi author non-byline.; Zeni Silvana author non-byline.; Mouthon Luc author non-byline.; Smith Vanessa author non-byline.; Cantatore Francesco Paolo author non-byline.; Corrado Ada author non-byline.; Ullman Susanne author non-byline.; Iversen Line author non-byline.; Pozzi Maria Rosa author non-byline.; Eyerich Kilian author non-byline.; Hein Rüdiger author non-byline.; Szechinski Jacek author non-byline.; Wiland Piotr author non-byline.; Krummel-Lorenz Brigitte author non-byline.; Aringer Martin author non-byline.; Westhovens Rene author non-byline.; De Langhe Ellen author non-byline.; Anic Branimir author non-byline.; Baresi Marko author non-byline.; Üprus Maria author non-byline.; Otsa Kati author non-byline.; Yavuz Sule author non-byline.; Radominski Sebastião Cezar author non-byline.; de Souza Müller Carolina author non-byline.; Jimenez Sergio author non-byline.; Busquets Joanna author non-byline.; Popa Sergei author non-byline.; Agachi Svetlana author non-byline.; Zenone Thierry author non-byline.; Mathieu Alessandro author non-byline.; Vacca Alessandra author non-byline.; Stamp Lisa author non-byline.; Chapman Peter author non-byline.; Tanaseanu Cristina-Mihaela author non-byline.; Popescu Monica author non-byline.; Foti Rosario author non-byline.; Rubio Silvia Rodriguez author non-byline.;
• Is Part Of: Annals of the rheumatic diseases. Volume 75:Issue 1(2016)
• Page Start: 103
• Page End: 109
• Publication Date: 2014-08-27
• Subjects: Systemic Sclerosis -- Synovitis -- Outcomes research; Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2014-205295
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Objective: To determine whether joint synovitis and tendon friction rubs (TFRs) can predict the progression of systemic sclerosis (SSc) over time. Patients and methods: We performed a prospective cohort study that included 1301 patients with SSc from the EUSTAR database with disease duration ≤3 years at inclusion and with a follow-up of at least 2 years. Presence or absence at clinical examination of synovitis and TFRs was extracted at baseline. Outcomes were skin, cardiovascular, renal and lung progression. Overall disease progression was defined according to the occurrence of at least one organ progression. Results: Joint synovitis (HR: 1.26, 95% CI 1.01 to 1.59) and TFRs (HR: 1.32, 95% CI 1.03 to 1.70) were independently predictive of overall disease progression, as were also the diffuse cutaneous subset (HR: 1.30, 95% CI 1.05 to 1.61) and positive antitopoisomerase-I antibodies (HR: 1.25, 95% CI 1.02 to 1.53). Regarding skin progression, joint synovitis (HR: 1.67, 95% CI 1.06 to 2.64) and TFRs (HR: 1.69, 95% CI 1.02 to 2.77) were also independently predictive of worsening of the modified Rodnan skin score. For cardiovascular progression, joint synovitis was predictive of the occurrence of new digital ulcer(s) (HR: 1.45, 95% CI 1.08 to 1.96) and decreased left ventricular ejection fraction (HR: 2.20, 95% CI 1.06 to 4.57); TFRs were confirmed to be an independent predictor of scleroderma renal crisis (HR: 2.33, 95% CI 1.03 to 6.19). Conclusions: Joint synovitis and TFRs are independent predictive factors for disease progression in patients with early SSc. These easily detected clinical markers may be useful for the risk stratification of patients with SSc.