A Protein‐Binding Molecular Photothermal Agent for Tumor Ablation. (6th May 2021)

• Record Type: Journal Article
• Authors: Shi, Mingwan; Fu, Zhongliang; Pan, Wei; Chen, Yuanyuan; Wang, Kaiye; Zhou, Ping; Li, Na; Tang, Bo
• Is Part Of: Angewandte Chemie. Volume 133:Number 24(2021)
• Page Start: 13676
• Page End: 13680
• Publication Date: 2021-05-06
• Subjects: cancer therapy -- molecular photothermal agent -- photothermal therapy -- protein binding -- tumor ablation; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202101009
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Photothermal therapy usually requires a high power density to activate photothermal agent for effective treatment, which inevitably leads to damage to normal tissues and inflammation in tumor tissues. Herein, we rationally design a protein‐binding strategy to build a molecular photothermal agent for photothermal ablation of tumor. The synthesized photothermal agent can covalently bind to the thiol groups on the intracellular proteins. The heat generated by the photothermal agent directly destroyed the bioactive proteins in the cells, effectively reducing the heat loss and the molecular leakage. Under a low power density of 0.2 W cm −2, the temperature produced by the photothermal agent was sufficient to induce apoptosis. In vitro and in vivo experiments showed that the therapeutic effect of photothermal therapy can be efficiently improved with the protein‐binding strategy. Abstract : A protein‐binding molecular photothermal agent was developed for photothermal therapy. In vitro and in vivo experiments demonstrated that the heat generated by the photothermal agent directly destroyed the intracellular bioactive proteins and induced apoptosis under low power density laser irradiation. The therapeutic effect can be efficiently improved with the protein‐binding strategy.