SAT0051 Vitamin D Levels and Inflammation in the Aortic Wall of Patients with Inflammatory Rheumatic Disease and Coronary Artery Disease. (23rd January 2014)

• Record Type: Journal Article
• Authors: Oma, I.; Lyberg, T.; Andersen, J. K.; Molberg, Ø.; Whist, J. E.; Kvelstad, I. L.; Veel, T.; Fagerland, M. W.; Almdahl, S. M.; Mikkelsen, K.; Hollan, I.
• Is Part Of: Annals of the rheumatic diseases. Volume 72:Supplement 3(2013)
• Page Start: A597
• Page End: A597
• Publication Date: 2014-01-23
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2013-eular.1777
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Background: Vitamin D is involved in immune reactions, and vitamin D deficiency is associated with autoimmune diseases and with cardiovascular diseases (CVDs). In Feiring Heart Biopsy Study (FHBS), we previously demonstrated a high occurrence of mononuclear cell infiltrates (MCIs) in subintimal layers of the aorta, related to inflammatory rheumatic disease (IRD). In theory, vitamin D deficiency might contribute to vascular inflammation involved in the pathogenesis of CVD along with the accelerated CVD in IRD. Objectives: To look for differences in plasma levels of 25(OH)D3 and 1, 25(OH)2 D3 in patients with coronary artery disease (CAD) with and without IRD. To search for relationships between inflammation in subintimal aortic layers (in terms of MCIs) and plasma levels of 25(OH)D3 and 1, 25(OH)2 D3 . Methods: Plasma levels of 25(OH)D3 were examined by radioimmunoassay and 1, 25(OH)2 D3 by immunoassay in 53 patients with CAD and 68 patients with CAD and IRD from FHBS. The D vitamin levels were then related to the number of MCI previously identified in the subintimal aortic layers of these patients 1 . Results: In crude analysis, we observed no significant differences in 25(OH)D3 and 1, 25(OH)2 D3 levels between patients with CAD and IRD and patients with CAD only (see Table ). Nor did we observe any significant crude associations between vitamin D levels and occurrence of MCIs in the subintimal aortic layers. However, after adjustment for age, sex, CRP, glucocorticosteroids, daily vitamin and mineral supplementation, and IRD status, patients with MCIs in the subintimal aortic layers had lower levels of 1, 25(OH)2 D3 than patients without (inter-group difference = 17.0 pmol/l (95%CI: 2.8 to 31.3), p=0.019). Conclusions: Our study does not support the hypothesis that patients with CVD and IRD have lower levels of vitamin D than patients with CVD only. Interestingly, based on multivariate analyses, low 1, 25(OH)2 D3 levels were associated with subintimal aortic inflammation. This finding should be explored in future studies. If a causal relationship exists, vitamin D supplementation could reduce vascular inflammation and thereby have potential therapeutic effect in CVD. References: I. Hollan et al ., Arthritis Rheum, 56 (2007), 2072-9. Disclosure of Interest: None Declared