Diagnostic accuracy of a two-stage model for detecting obstructive sleep apnoea in chronic tetraplegia. Issue 9 (7th May 2018)

• Record Type: Journal Article
• Authors: Graco, Marnie; Schembri, Rachel; Cross, Susan; Thiyagarajan, Chinnaya; Shafazand, Shirin; Ayas, Najib T; Nash, Mark S; Vu, Viet H; Ruehland, Warren R; Chai-Coetzer, Ching Li; Rochford, Peter; Churchward, Thomas; Green, Sally E; Berlowitz, David J
• Is Part Of: Thorax. Volume 73:Issue 9(2018)
• Page Start: 864
• Page End: 871
• Publication Date: 2018-05-07
• Subjects: sleep apnoea -- clinical epidemiology -- respiratory measurement; Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thoraxjnl-2017-211131
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : Background: Obstructive sleep apnoea (OSA) is highly prevalent in people with spinal cord injury (SCI). Polysomnography (PSG) is the gold-standard diagnostic test for OSA, however PSG is expensive and frequently inaccessible, especially in SCI. A two-stage model, incorporating a questionnaire followed by oximetry, has been found to accurately detect moderate to severe OSA (MS-OSA) in a non-disabled primary care population. This study investigated the accuracy of the two-stage model in chronic tetraplegia using both the original model and a modified version for tetraplegia. Methods: An existing data set of 78 people with tetraplegia was used to modify the original two-stage model. Multivariable analysis identified significant risk factors for inclusion in a new tetraplegia-specific questionnaire. Receiver operating characteristic (ROC) curve analyses of the questionnaires and oximetry established thresholds for diagnosing MS-OSA. The accuracy of both models in diagnosing MS-OSA was prospectively evaluated in 100 participants with chronic tetraplegia across four international SCI units. Results: Injury completeness, sleepiness, self-reported snoring and apnoeas were included in the modified questionnaire, which was highly predictive of MS-OSA (ROC area under the curve 0.87 (95% CI 0.79 to 0.95)). The 3% oxygen desaturation index was also highly predictive (0.93 (0.87–0.98)). The two-stage model with modified questionnaire had a sensitivity and specificity of 83% (66–93) and 88% (75–94) in the development group, and 77% (65–87) and 81% (68–90) in the validation group. Similar results were demonstrated with the original model. Conclusion: Implementation of this simple alternative to full PSG could substantially increase the detection of OSA in patients with tetraplegia and improve access to treatments. Trial registration number: Results, ACTRN12615000896572 (The Australian and New Zealand Clinical Trials Registry) and pre-results, NCT02176928 (clinicaltrials.gov).