B-type natriuretic peptide in reversible myocardial ischaemia. Issue 11 (27th October 2006)

• Record Type: Journal Article
• Authors: Chatha, K; Alsoud, M; Griffiths, M J; Elfatih, A; Abozguia, K; Horton, R C; Dunmore, S J; Gama, R
• Is Part Of: Journal of clinical pathology. Volume 59:Issue 11(2006)
• Page Start: 1216
• Page End: 1217
• Publication Date: 2006-10-27
• Subjects: BNP, B-type natriuretic peptide -- CHD, Coronary heart disease -- ETT, electrocardiogram test -- NT-proBNP, N-terminal proBNP; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.2005.034702
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Background: Coronary heart disease is associated with increased B-type natriuretic peptides (BNPs), and, although controversial, may cause exaggerated exercise-induced BNP secretion. We investigated BNP in relation to reversible myocardial ischaemia. Materials and methods: Serum N-terminal proBNP (NT-proBNP) was measured before and after an exercise electrocardiogram test (ETT) in 14 patients with and 45 patients without exercise-induced myocardial ischaemia. Statistical analysis was carried out on logarithmically transformed data. Results, however, are pre-transformed data. Results: NT-proBNP increased with exercise both in ETT-positive patients (mean (SD) 71.4 (41.2) v 76.8 (44.0) ng/l; p<0.001) and ETT-negative patients (54.0 (61.2) v 60.1 (69.0) ng/l; p<0.001). Pre-exercise and post-exercise NT-proBNP were higher (p<0.05) in ETT-positive than in ETT-negative patients. Incremental NT-proBNP was similar in ETT-positive (4.7 (4.2) ng/l) and ETT-negative (6.2 (8.6) ng/l) patients. Conclusion: Serum NT-proBNP concentrations are higher in patients with exercise-induced myocardial ischaemia than in those without. Exercise-induced electrocardiographic myocardial ischaemia, however, is not associated with exaggerated BNP secretion.