Effects of growth factors and receptor blockade on gastrointestinal cancer. Issue 8 (9th July 2004)

• Record Type: Journal Article
• Authors: Playford, R J; Wassan, H; Ghosh, S
• Is Part Of: Gut. Volume 53:Issue 8(2004)
• Page Start: 1059
• Page End: 1063
• Publication Date: 2004-07-09
• Subjects: EGF, epidermal growth factor -- EGFR, epidermal growth factor receptor -- GLP-2, glucagon-like peptide 2 -- TGF-β, transforming growth factor β -- GnRH, gonadotrophin releasing hormone -- TKI, tyrosine kinase inhibitor; epidermal growth factor -- receptor blockade -- gastrointestinal cancer -- growth factor receptors; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.2003.038620
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : The advent of recombinant peptide technology offers the potential to use one or several peptides to treat a variety of gastrointestinal conditions. However, although cell culture and animal models have shown proof of concept, we are still at a relatively early stage in translating their use to standard clinical practice. Similarly, peptide and non-peptide antagonists of growth factor receptors show great potential as novel antichemotherapy agents. However, their actual place in clinical practice has yet to be established.