Health state utility values in schizophrenia: protocol for a systematic review and meta-analysis. Issue 4 (24th May 2019)

• Record Type: Journal Article
• Authors: Aceituno, David; Pennington, Mark; Iruretagoyena, Barbara; Prina, Matthew A; McCrone, Paul
• Is Part Of: Evidence-based mental health. Volume 22:Issue 4(2019)
• Page Start: 142
• Page End: 144
• Publication Date: 2019-05-24
• Subjects: adult psychiatry; Psychotherapy -- Periodicals; Psychiatry -- Periodicals; Mental health -- Periodicals; 616.891
• DOI: 10.1136/ebmental-2019-300089
• Languages: English
• ISSNs: 1362-0347

Abstract

Abstract : Introduction: Cost-effectiveness analyses that use quality-adjusted life-years (QALYs) allow comparing the value for money of interventions across different health problems. Health state utility values (HSUVs) are crucial to calculate QALYs. These are weights attached to a given health state reflecting preferences in health-related quality of life (HRQoL). In schizophrenia, there is extensive evidence about the consequences of this condition on HRQoL. Besides, several interventions have claimed to be cost-effective in terms of QALYs gained. Despite this evidence, a systematic review of HSUVs has not been conducted. Therefore, we aim to synthesise the evidence about HSUVs in schizophrenia. Methods and analysis: We will conduct a systematic review of the literature about HSUVs in people with schizophrenia following the Preferred Reporting Items for Systematic review and Meta-Analysis and the International Society for Pharmacoeconomics and Outcomes Research task force recommendations. The submissions records of eight electronic peer-reviewed databases and three health technology assessment (HTA) agencies will be searched. Quantitative synthesis will be carried out in comparable studies, using random-effects meta-analysis. Heterogeneity will be explored using meta-regression if more than 10 studies per covariate are found. A narrative synthesis and methodological quality of included studies will be also reported. Discussion: This review will provide a synthesis of the HSUVs estimated for different states experienced by people with schizophrenia. This will inform analysts when calculating QALYs, using values in a more transparent and accountable manner. Finally, it will shed light on evidence gaps and limitations about this measure in mental health. PROSPERO registration number: CRD42019123582.