Influence of diabetes mellitus on coronary collateral flow: an answer to an old controversy. Issue 10 (14th September 2005)

• Record Type: Journal Article
• Authors: Zbinden, R; Zbinden, S; Billinger, M; Windecker, S; Meier, B; Seiler, C
• Is Part Of: Heart. Volume 91:Issue 10(2005)
• Page Start: 1289
• Page End: 1293
• Publication Date: 2005-09-14
• Subjects: CAD, coronary artery disease -- CFI, collateral flow index -- CFIp, pressure derived collateral flow index -- CFIv, velocity derived collateral flow index -- CVP, central venous pressure -- DM, diabetes mellitus -- Pao, mean aortic pressure -- Poccl, distal coronary pressure at the end of a one minute balloon occlusion; collateral circulation -- diabetes mellitus -- angiogenesis -- collateral flow index; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.2004.041236
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objectives: To determine the influence of diabetes mellitus on coronary collateral flow by accurate means of collateral flow measurement in a large population with variable degrees of coronary artery disease. Methods: 200 patients (mean (SD) age 64 (9) years; 100 diabetic and 100 non-diabetic) were enrolled in the study. Coronary collateral flow was assessed in 174 stenotic and in 26 angiographically normal vessels with a pressure guidewire (n = 131), Doppler guidewire (n = 36), or both (n = 33) to calculate pressure or flow velocity derived collateral flow index (CFI). Diabetic patients were perfectly matched with a non-diabetic control group for clinical, haemodynamic, and angiographic parameters. Results: CFI did not differ between the diabetic and the non-diabetic patients (0.21 (0.12) v 0.19 (0.13), not significant). Likewise, CFI did not differ when only angiographically normal vessels (0.20 (0.09) v 0.15 (0.08), not significant) or chronic total coronary occlusions (0.30 (0.14) v 0.30 (0.17), not significant) were compared. Fewer patients in the diabetic group tended to have angina pectoris during the one minute vessel occlusion (60 diabetic v 69 non-diabetic patients, p = 0.15). Conclusion: Quantitatively measured coronary CFI did not differ between diabetic and non-diabetic patients with stable coronary artery disease.