AB0710 Histological evaluation of enlarged submandibular glands in the diagnosis of systemic diseases. (23rd January 2014)

• Record Type: Journal Article
• Authors: Sedyshev, S.; Vasilyev, V.; Gayduk, I.; Kovrigina, A.; Logvinenko, O.; Borovskaya, A.
• Is Part Of: Annals of the rheumatic diseases. Volume 71(2012)Supplement 3
• Page Start: 679
• Page End: 679
• Publication Date: 2014-01-23
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/annrheumdis-2012-eular.710
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Objectives: To evaluate the diagnostic of histological and immunomorphological studies of enlarged submandibular salivary glands (SSG) in the diagnosis of systemic diseases. Methods: We examined 14 patients (male – 4, female - 10), mean age - 52.4 years (26 - 76) with unilateral or bilateral enlargement of SSG. All the patients were taken samples of SSG tissue. The applied techniques were extirpation of the SSG (n=8), incisional biopsy (n=3), needle biopsy (n=2), autopsy (n=1). In all cases histological and immunomorphological examination of SSG tissue. Eleven patients had xerostomia. Sialography showed parenchymal sialadenitis in 3 patients. Six patients had markers of autoimmune diseases (rheumatoid factor, antinuclear antibodies, anti-SSA, anti-SSB, ACCP, hypergammaglobulinemia), 4 – had signs of acute inflammation (CRP, elevated ESR). Histological study of enlarged submandibular salivary glands, especially when using a minimally invasive incisional biopsy, is a useful and informative method of diagnosing a wide range of systemic diseases. Results: Most patients are sent for examination with suspected primary Sjögren's syndrome (n=6), sclerosing sialadenitis (n=4) or primary NHL (n=2). While the survey the initial diagnosis was withdrawn in 13 patients. On the basis of clinical, laboratory, histological and immunomorphological examination 6 patients were diagnosed with IgG4-RSD (Mikulicz's disease (n=2), Küttner's tumor (n=1), multifocal fibrosclerosos (n=2). In 7 cases various lymphoproliferative disease were diagnosed (MALT-lymphoma+rheumatoid arthritis (n=3), MALT-lymphoma+ pSS (n=1), primary AL-amyloidosis (n=2) and primary NHL (n=1). Generalized sarcoidosis was shown in 1 patient. Conclusions: Histological study of enlarged submandibular salivary glands, especially when using a minimally invasive incisional biopsy, is a useful and informative method of diagnosing a wide range of systemic diseases. Disclosure of Interest: None Declared