Serum soluble VSIG4 as a surrogate marker for the diagnosis of lymphoma‐associated hemophagocytic lymphohistiocytosis. (21st January 2020)

• Record Type: Journal Article
• Authors: Yuan, Shunzong; Wang, Yanqing; Luo, Hui; Jiang, Zheng; Qiao, Bing; Jiang, Yan; Hu, Yaning; Cheng, Yang; Chen, Xilin; Gong, Weihua; Huang, Yong; Zhao, Weipeng; Luo, Deyan; Liu, Bing; Su, Hang; Zhou, Jianfeng; Song, Shiping
• Is Part Of: British journal of haematology. Volume 189:Number 1(2020)
• Page Start: 72
• Page End: 83
• Publication Date: 2020-01-21
• Subjects: lymphoma -- haemophagocytic lymphohistiocytosis -- VSIG4 -- macrophage -- biomarker; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.16299
• Languages: English
• ISSNs: 0007-1048

Abstract

Summary: Lymphoma‐associated haemophagocytic lymphohistiocytosis (L‐HLH) is characterized by excessively activated macrophages and cytotoxic T lymphocytes, but few reliable markers for activated macrophages are available clinically. This study, designed to discover novel biomarkers for the diagnosis of lymphoma patients with L‐HLH, was initiated between 2016 and 2018. Fifty‐seven adult lymphoma patients were enrolled — 39 without HLH and 18 with HLH. The differential serum protein expression profile was first screened between lymphoma patients with and without L‐HLH by a quantitative mass spectrometric approach. Soluble V‐set and immunoglobulin domain‐containing 4 (sVSIG4), specifically expressed by macrophages, was significantly upregulated in the L‐HLH group. Subsequently, sVSIG4 concentration was confirmed by enzyme‐linked immunosorbent assay to be significantly increased in lymphoma patients with L‐HLH. When it was exploited for the diagnosis of lymphoma patients with L‐HLH, the area under a receiver operating characteristic curve was 0·98 with an optimal cut‐off point of 2195 pg/ml and the corresponding sensitivity and specificity were 94·44% and 94·87% respectively. In addition, the one‐year overall survival was significantly worse in patients with a sVSIG4 concentration above 2195 pg/ml compared with those below 2195 pg/ml (5·3% vs. 72·2%, P < 0·0001). sVSIG4 may be a surrogate marker of activated macrophages for the diagnosis of lymphoma patients with L‐HLH.