1585 Association of shift-work, daytime napping, and nighttime sleep with cancer incidence and cancer-caused mortality in dongfeng-tongji cohort study. (24th April 2018)

• Record Type: Journal Article
• Authors: Bai, Yansen; Li, Xiaoliang; Wang, Ke; Chen, Shi; Wang, Suhan; Chen, Zhuowang; Wu, Xiulong; Fu, Wenshan; Wei, Sheng; Yuan, Jing; Yao, Ping; Miao, Xiaoping; Zhang, Xiaomin; He, Meian; Yang, Handong; Wu, Tangchun; Guo, Huan
• Is Part Of: Occupational and environmental medicine. Volume 75(2018)Supplement 2
• Page Start: A489
• Page End: A490
• Publication Date: 2018-04-24
• Subjects: Sleep habits -- Cancer incidence -- Cancer-caused mortality; Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; 616.980305
• DOI: 10.1136/oemed-2018-ICOHabstracts.1394
• Languages: English
• ISSNs: 1351-0711

Abstract

Abstract : Introduction: More than 30% of cancer deaths could be prevented by modifying or avoiding risk factors, such as unhealthy living habits, including night-shift work, daytime napping, and nighttime sleep. We aimed to investigate the independent and combined effects of these three sleep habits on cancer incidence and cancer-caused mortality among middle-aged and older Chinese in the Dongfeng-Tongji Cohort Study (27 009 retired workers were recruited from Dong-Feng Motor Corporation (DMC) in 2008, and 25 978 participants were successfully followed-up during the first follow-up period from June, 2013 to October, 2013). During 1 14 162 person-years of follow up, we identified a total of 1251 cancer cases and 379 cancer-caused deaths. Methods: Information on sleep habits, cancer incidences and mortalities were collected at baseline 2008. Self-reported cancer incidences and cancer-caused deaths were confirmed from DMC's health-care service system, which consists of five DMC-owned hospitals that covers all retired employees. Cox proportional hazards models were used to calculate the adjusted hazard ratios and 95% confidence intervals (HRs, 95% CIs). Results: Males experienced ≥20 years of night-shift work, or no daytime napping had increased cancer incidence, when compared to males who did not have night-shift work or had daytime napping for 1~30 min [HR(95% CI)=1.27(1.01–1.59), 2.03 (1.007–4.13), respectively]. Males who slept ≥10 hours/night had a 40% increase in cancer incidence and 59% increase in cancer-caused mortality than males who slept 7~8 hours/night [HR (95% CI)=1.40(1.04–1.88) and 1.59 (1.01–2.49), respectively]. There was an interaction effect between night-shift work of ≥20 years and sleep of ≥10 hours/night on cancer incidence (Pinteraction =0.027). Conclusion: For male subjects, both long night-shift work (≥20 years) and nighttime sleep duration (≥10 hours) were independently and jointly associated with higher cancer incidence.