11 THE RISK OF NEPHROLITHIASIS IN SPONDYLOARTHRITIS. (1st March 2005)

• Record Type: Journal Article
• Authors: Leonard, S. A.; Singh, J. A.; Krug, H. E.
• Is Part Of: Journal of investigative medicine. Volume 53:Number 2(2005)
• Page Start: S358
• Page End: S358
• Publication Date: 2005-03-01
• Subjects: Clinical medicine -- Periodicals; Medicine -- Research -- Periodicals; Medicine; Research -- United States; Clinical medicine; Medicine -- Research; Periodicals; 616.075
• DOI: 10.2310/6650.2005.00206.10
• Languages: English
• ISSNs: 1081-5589

Abstract

Abstract : Purpose: Inflammatory arthritis is not generally considered a risk factor for nephrolithiasis; however previous studies have found a higher point prevalence of nephrolithiasis in rheumatoid arthritis than the general population. A 1973 study reported an increased incidence of renal stones in patients with spondyloarthritis (SPA) as compared with rheumatoid arthritis (RA) controls (Mladenovic et al, Rheumatizm 1973;20:106-110). Our objective was to confirm this cross-sectional study with a cohort study comparing lifetime prevalence of nephrolithiasis in patients with (SPA) and (RA). Methods: This study was designed as a VA retrospective cohort study. The study group was obtained from patients followed in the Minneapolis VA, with the diagnoses of SPA. Controls were rheumatoid factor positive, RA patients. The sample size was calculated by using an alpha of 0.05, a power of 0.80, an estimated prevalence of nephrolithiasis in the RA group of 5% and a 16% in the SPA patients. Controls are age and sex matched. The prevalence rate for the controls was estimated from the United States National Health and Nutritional Examination Survey II. Each patient was surveyed regarding their rheumatologic diagnosis, relevant coexistent conditions and history of kidney stones. Patient-reported history of kidney stones was confirmed whenever possible by chart review. All patients met ACR criteria for either RA or SPA. Results: Forty-nine SPA patients and 27 RA patients have been enrolled. Our goal is to enroll 250 patients (84 SPA patients and 168 RA patients). These results will be discussed at the time of presentation. To date 16/49 (32.7%) SPA patients reported a history of renal stones compared with 4/27 (14.8%) RA patients. Chi square equals 3.95 (p=0.047). Four patients with kidney stones in the SPA group and 2/4 patients in the control group had other risk factors for stones. Conclusion: These results show an increase in the prevalence of kidney stones in SPA compared to RA. This is similar to the findings of Mladenovic et al. These results suggest that other studies should be done to ascertain the cause of increased nephrolithiasis in SPA.